Koetsawang S, Shrimanker K, Fotherby K
Contraception. 1979 Jul;20(1):1-4. doi: 10.1016/0010-7824(79)90038-6.
Mean levels of MPA in blood taken 90 days after injection were not significantly different between women who had received a single injection of DepoPrevera and those who had received eight injections at 90-day intervals. There was a wide variation in plasma MPA concentration in the two groups of women. In women who had received 31 to 45 injections of CycloProvera, plasma levels of MPA 28 days after injection were significantly higher than those of women who had received a single injection. The levels were also higher than those found in women 90 days after injection of DepoProvera. The results suggest that the dose of MPA in CycloProvera could be reduced.
注射90天后采集的血液中，接受单次注射醋酸甲羟孕酮（DepoPrevera）的女性与接受每90天注射一次、共注射八次的女性相比，醋酸甲羟孕酮的平均水平无显著差异。两组女性的血浆醋酸甲羟孕酮浓度差异很大。接受31至45次注射醋酸甲羟孕酮（CycloProvera）的女性，注射后28天的血浆醋酸甲羟孕酮水平显著高于接受单次注射的女性。这些水平也高于注射醋酸甲羟孕酮（DepoPrevera）90天后女性的水平。结果表明，醋酸甲羟孕酮（CycloProvera）中的醋酸甲羟孕酮剂量可以降低。
