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1
The synthesis of pteroylpolyglutamates by sheep liver enzymes in vitro.绵羊肝脏酶体外合成蝶酰多聚谷氨酸。
Biochem J. 1973 Oct;136(2):295-301. doi: 10.1042/bj1360295.
2
Enzymatic conversion of 5-oxo-L-proline (L-pyrrolidone carboxylate) to L-glutamate coupled with cleavage of adenosine triphosphate to adenosine diphosphate, a reaction in the -glutamyl cycle.5-氧代-L-脯氨酸（L-吡咯烷酮羧酸盐）酶促转化为L-谷氨酸，并伴有三磷酸腺苷裂解为二磷酸腺苷，这是γ-谷氨酰循环中的一个反应。
Proc Natl Acad Sci U S A. 1971 Dec;68(12):2982-5. doi: 10.1073/pnas.68.12.2982.
3
Subcellular localization of gamma-glutamyl carboxypeptidase and of folates.
Biochim Biophys Acta. 1976 Oct 22;444(3):794-801. doi: 10.1016/0304-4165(76)90326-3.
4
Studies on the absorption and metabolism of folic acid. I. Folate absorption in the dog after exposure of isolated intestinal segments to synthetic pteroylpolyglutamates of various chain lengths.叶酸的吸收与代谢研究。I. 离体肠段暴露于不同链长的合成蝶酰多谷氨酸后犬体内的叶酸吸收情况。
J Clin Invest. 1971 Oct;50(10):2009-21. doi: 10.1172/JCI106694.
5
[Effect of folic acid deficiency on the synthesis of pteroylpolyglutamates].[叶酸缺乏对蝶酰多谷氨酸合成的影响]
Acta Vitaminol Enzymol. 1983;5(4):225-8.
6
Biosynthesis of folate polyglutamate in the rat with different tracers.用不同示踪剂研究大鼠体内叶酸多聚谷氨酸的生物合成。
Clin Sci Mol Med. 1977 Jan;52(1):83-6. doi: 10.1042/cs0520083.
7
Exchange of palmitic acid from cytosolic proteins to microsomes, mitochondria and lipid vesicles.棕榈酸从胞质蛋白向微粒体、线粒体和脂质囊泡的交换。
Acta Physiol Lat Am. 1982;32(4):267-76.
8
Polyglutamate forms of folate in liver of folic acid-deficient rats.
Int J Vitam Nutr Res. 1979;49(1):64-9.
9
Pteroylpoly(gamma-glutamate) synthesis by Corynebacterium species. In vivo synthesis of folates.棒杆菌属细菌合成蝶酰多（γ-谷氨酸）。体内叶酸的合成。
J Biol Chem. 1980 Jun 25;255(12):5649-54.
10
Some characteristics of the dihydrofolate synthetase from Serratia indica.印度沙雷氏菌二氢叶酸合成酶的一些特性。
J Nutr Sci Vitaminol (Tokyo). 1976;22(5):365-73. doi: 10.3177/jnsv.22.365.

引用本文的文献

1
Enzymatic synthesis and function of folylpolyglutamates.叶酰聚谷氨酸的酶促合成与功能
Mol Cell Biochem. 1981 Aug 11;38 Spec No(Pt 1):19-48. doi: 10.1007/BF00235686.
2
Chronic cobalamin inactivation impairs folate polyglutamate synthesis in the rat.慢性钴胺素失活会损害大鼠体内叶酸多聚谷氨酸的合成。
J Clin Invest. 1983 May;71(5):1183-90. doi: 10.1172/jci110867.
3
Pteroylpolyglutamates.蝶酰多聚谷氨酸盐
Mol Cell Biochem. 1981 Sep 25;39:331-45. doi: 10.1007/BF00232583.
4
Folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells.细菌和哺乳动物细胞合成叶酰多聚-γ-谷氨酸
Mol Cell Biochem. 1981 Sep 25;39:209-28. doi: 10.1007/BF00232575.
5
Folic acid metabolism in vitamin B12-deficient sheep. Effects of injected methionine on methotrexate transport and the activity of enzymes associated with folate metabolism in liver.维生素B12缺乏绵羊的叶酸代谢。注射蛋氨酸对甲氨蝶呤转运及肝脏中与叶酸代谢相关酶活性的影响。
Biochem J. 1974 Jul;142(1):119-26. doi: 10.1042/bj1420119.
6
Folic acid metabolism in vitamin B12-deficient sheep. Effects of injected methionine on liver constituents associated with folate metabolism.维生素B12缺乏绵羊的叶酸代谢。注射蛋氨酸对与叶酸代谢相关的肝脏成分的影响。
Biochem J. 1974 Jul;142(1):105-17. doi: 10.1042/bj1420105.
7
The relationships between vitamin B12 and folic acid and the effect of methionine on folate metabolism.维生素B12与叶酸之间的关系以及蛋氨酸对叶酸代谢的影响。
Mol Cell Biochem. 1975 Nov 14;9(2):97-108. doi: 10.1007/BF01732201.
8
The distribution and chemical nature of radioactive folates in rat liver cells and rat liver mitochondria.放射性叶酸在大鼠肝细胞和大鼠肝线粒体中的分布及化学性质。
Biochem J. 1979 Mar 15;178(3):651-9. doi: 10.1042/bj1780651.

本文引用的文献

1
Metabolism of propionate by sheep liver. Stimulation of the mitochondrial rate by factors from the cell sap.绵羊肝脏中丙酸的代谢。细胞液中的因子对线粒体速率的刺激作用。
Biochem J. 1965 May;95(2):423-30. doi: 10.1042/bj0950423.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
MEASUREMENT OF LOW ENERGY BETA-EMITTERS IN AQUEOUS SOLUTION BY LIQUID SCINTILLATION COUNTING OF EMULSIONS.通过乳液的液体闪烁计数法测量水溶液中的低能β发射体。
Anal Chem. 1965 Jun;37:854-7. doi: 10.1021/ac60226a017.
4
THE BIOSYNTHESIS OF FOLIC ACID. III. ENZYMATIC FORMATION OF DIHYDROFOLIC ACID FROM DIHYDROPTEROIC ACID AND OF TETRAHYDROPTEROYLPOLYGLUTAMIC ACID COMPOUNDS FROM TETRAHYDROFOLIC ACID.叶酸的生物合成。III. 由二氢蝶酸酶促形成二氢叶酸以及由四氢叶酸形成四氢蝶酰多谷氨酸化合物。
J Biol Chem. 1964 Jan;239:310-6.
5
The reaction of tetrahydropteroylglutamic acid and related hydropteridines with formaldehyde.四氢蝶酰谷氨酸及相关蝶啶与甲醛的反应
Biochem J. 1959 Aug;72(4):707-15. doi: 10.1042/bj0720707.
6
The reduction of folate by borohydride.硼氢化物对叶酸的还原作用。
Biochemistry. 1966 Apr;5(4):1438-43. doi: 10.1021/bi00868a042.
7
Naturally occurring folates in the blood and liver of the rat.大鼠血液和肝脏中的天然叶酸。
Anal Biochem. 1965 Jul;12(1):18-35. doi: 10.1016/0003-2697(65)90138-7.
8
Folic acid metabolism.叶酸代谢
Physiol Rev. 1967 Jan;47(1):83-116. doi: 10.1152/physrev.1967.47.1.83.
9
Influence of vitamin B12 and methionine on levels of folic acid compounds and folate enzymes in rat liver.维生素B12和蛋氨酸对大鼠肝脏中叶酸化合物及叶酸酶水平的影响。
Proc Soc Exp Biol Med. 1967 Mar;124(3):801-5. doi: 10.3181/00379727-124-31857.
10
Folic acid metabolism in vitamin B12-deficient sheep. Depletion of liver folates.维生素B12缺乏绵羊的叶酸代谢。肝脏叶酸的消耗。
Biochem J. 1973 Oct;136(2):279-93. doi: 10.1042/bj1360279.

绵羊肝脏酶体外合成蝶酰多聚谷氨酸。

The synthesis of pteroylpolyglutamates by sheep liver enzymes in vitro.

作者信息

Gawthorne J M, Smith R M

出版信息

Biochem J. 1973 Oct;136(2):295-301. doi: 10.1042/bj1360295.

DOI:10.1042/bj1360295
PMID:4774396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1165954/
Abstract
  1. Sephadex G-15 was used to separate pteroylmonoglutamates from corresponding polyglutamate derivatives. 2. Pteroylpolyglutamates were formed when 5-formyltetrahydro[2-(14)C]pteroylglutamic acid, 5-[methyl-(14)C]tetrahydropteroylglutamic acid or tetrahydro[2-(14)C]pteroylglutamic acid was incubated at pH8.4 with ATP, MgCl(2), KCl, l-glutamic acid and sheep liver cytosol. The gamma-glutamyl side chain appeared to be lengthened by the stepwise addition of single glutamate moieties. 3. The subcellular distribution of pteroylpolyglutamates paralleled that of pteroylpolyglutamate synthetase activity, and followed the order cytosol>;nuclear' fraction>microsomal fraction>mitochondria.
摘要
  1. 用葡聚糖凝胶G - 15从相应的多聚谷氨酸衍生物中分离蝶酰单谷氨酸。2. 当5 - 甲酰四氢[2 - (14)C]蝶酰谷氨酸、5 - [甲基 - (14)C]四氢蝶酰谷氨酸或四氢[2 - (14)C]蝶酰谷氨酸在pH8.4条件下与ATP、MgCl₂、KCl、L - 谷氨酸和羊肝细胞溶胶一起温育时，会形成蝶酰多聚谷氨酸。γ - 谷氨酰侧链似乎是通过逐个添加单个谷氨酸部分而延长的。3. 蝶酰多聚谷氨酸的亚细胞分布与蝶酰多聚谷氨酸合成酶活性的分布平行，顺序为细胞溶胶＞核部分＞微粒体部分＞线粒体。