• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

2-卤代乙醇对α-糜蛋白酶的抑制作用；与2-甲基乙醇和尿素的比较。

Inhibition of alpha-chymotrypsin by 2-halogeno-ethanols; comparisons with 2-methyl-ethanols and urea.

作者信息

Ebina S, Kobayashi T, Nagai Y

出版信息

Experientia. 1979 Aug 15;35(8):1011-2. doi: 10.1007/BF01949911.

DOI:10.1007/BF01949911
PMID:477859
Abstract

2-Halogeno- and 2-methyl-ethanols inhibit alpha-chymotrypsin in the order of their substituted groups: [1] tri- greater than di- greater than mono-, [2] Br- greater than Cl- greater than CH3- greater than F-. The inhibition by the halogeno-ethanols is mediated differently from that by the methyl-ethanols, ethanol, and urea.

摘要

2-卤代乙醇和2-甲基乙醇按其取代基团的顺序抑制α-胰凝乳蛋白酶：[1]三取代大于二取代大于单取代，[2]溴大于氯大于甲基大于氟。卤代乙醇的抑制作用与甲基乙醇、乙醇和尿素的抑制作用介导方式不同。

相似文献

1
Inhibition of alpha-chymotrypsin by 2-halogeno-ethanols; comparisons with 2-methyl-ethanols and urea.2-卤代乙醇对α-糜蛋白酶的抑制作用；与2-甲基乙醇和尿素的比较。
Experientia. 1979 Aug 15;35(8):1011-2. doi: 10.1007/BF01949911.
2
Active site structural change of alpha-chymotrypsin due to 2-halogeno-ethanols; comparison with ethanol, I-propanol, and urea.
Experientia. 1980 May 15;36(5):534-5. doi: 10.1007/BF01965782.
3
2-halogeno-ethanols as denaturant of protein. Activity coefficient of N-acetyl ethyl esters of aromatic amino acids in 2-fluoroethanol, 2,2,2-trifluoroethanol, 2-chloroethanol, 2-bromoethanol, 1-propanol, and ethanol.2-卤代乙醇作为蛋白质变性剂。芳香族氨基酸的N-乙酰乙酯在2-氟乙醇、2,2,2-三氟乙醇、2-氯乙醇、2-溴乙醇、1-丙醇和乙醇中的活度系数。
Fukushima J Med Sci. 1982;28(3-4):83-92.
4
2-Halogeno-ethanols as an uncoupler of phosphorylation in rat liver mitochondria.2-卤代乙醇作为大鼠肝线粒体磷酸化解偶联剂
Experientia. 1980 May 15;36(5):537-9. doi: 10.1007/BF01965784.
5
A simple procedure for the photoregulation of chymotrypsin activity.一种用于光调节胰凝乳蛋白酶活性的简单方法。
Photochem Photobiol Sci. 2006 Mar;5(3):326-30. doi: 10.1039/b515146e. Epub 2006 Jan 19.
6
Synthesis, structure-activity relationships studies of benzoxazinone derivatives as α-chymotrypsin inhibitors.苯并恶嗪酮衍生物作为 α-糜蛋白酶抑制剂的合成及构效关系研究。
Bioorg Chem. 2017 Feb;70:210-221. doi: 10.1016/j.bioorg.2017.01.001. Epub 2017 Jan 4.
7
Kinetics and stoichiometry of inactivation of some pancreatic and leucocyte serine proteinases by rabbit alpha 1-proteinase inhibitors F and S.兔α1-蛋白酶抑制剂F和S对某些胰腺和白细胞丝氨酸蛋白酶的失活动力学及化学计量学
Biomed Biochim Acta. 1983;42(10):1221-8.
8
On the irreversible inhibition of alpha-chymotrypsin, trypsin, pancreatic kallikrein, thrombin and elastase by N-(beta-pyridylmethyl)-3,4-dichlorophenoxyacetamide-p-fluorosulfonylacetanilide bromide.
Biochim Biophys Acta. 1973 Sep 15;321(1):296-302. doi: 10.1016/0005-2744(73)90084-3.
9
Compounds that inhibit chymotrypsin and cell replication.抑制胰凝乳蛋白酶和细胞复制的化合物。
Biochem Pharmacol. 1986 Oct 15;35(20):3587-91. doi: 10.1016/0006-2952(86)90630-1.
10
Inhibition of alpha-chymotrypsin by dibenamine.二苯胺对α-胰凝乳蛋白酶的抑制作用。
J Pharm Pharmacol. 1974 Aug;26(8):612-5. doi: 10.1111/j.2042-7158.1974.tb10673.x.

引用本文的文献

1
2-Halogeno-ethanols as an uncoupler of phosphorylation in rat liver mitochondria.2-卤代乙醇作为大鼠肝线粒体磷酸化解偶联剂
Experientia. 1980 May 15;36(5):537-9. doi: 10.1007/BF01965784.
2
Active site structural change of alpha-chymotrypsin due to 2-halogeno-ethanols; comparison with ethanol, I-propanol, and urea.
Experientia. 1980 May 15;36(5):534-5. doi: 10.1007/BF01965782.

本文引用的文献

1
Some factors in the interpretation of protein denaturation.蛋白质变性解读中的一些因素。
Adv Protein Chem. 1959;14:1-63. doi: 10.1016/s0065-3233(08)60608-7.
2
THE SOLUBILITY OF AMINO ACIDS AND RELATED COMPOUNDS IN AQUEOUS UREA SOLUTIONS.氨基酸及相关化合物在尿素水溶液中的溶解度
J Biol Chem. 1963 Dec;238:4074-81.
3
A new spectrophotometric method for the determination of chymotrypsin activity.一种测定胰凝乳蛋白酶活性的新分光光度法。
Anal Biochem. 1962 May;3:431-5. doi: 10.1016/0003-2697(62)90072-6.
4
Three-dimensional structure of tosyl-alpha-chymotrypsin.甲苯磺酰-α-胰凝乳蛋白酶的三维结构。
Nature. 1967 May 13;214(5089):652-6. doi: 10.1038/214652a0.
5
Role of a buried acid group in the mechanism of action of chymotrypsin.一个埋藏的酸性基团在胰凝乳蛋白酶作用机制中的作用。
Nature. 1969 Jan 25;221(5178):337-40. doi: 10.1038/221337a0.
6
On the structural stability and solvent denaturation of proteins. II. Denaturation by the ureas.
J Biol Chem. 1970 Sep 10;245(17):4544-50.
7
Structure of crystalline -chymotrypsin. V. The atomic structure of tosyl- -chymotrypsin at 2 A resolution.结晶胰凝乳蛋白酶的结构。V. 对甲苯磺酰基-胰凝乳蛋白酶在2埃分辨率下的原子结构
J Mol Biol. 1972 Jul 21;68(2):187-240. doi: 10.1016/0022-2836(72)90210-0.
8
The charge-relay system of serine proteinases: proton magnetic resonance titration studies of the four histidines of porcine trypsin.
J Mol Biol. 1976 Apr 15;102(3):487-509. doi: 10.1016/0022-2836(76)90330-2.