Lafille C, Barbier A, Girard J
Dermatologica. 1979;159(4):277-89.
Comparative study of experimental and theoretical curves obtained by plotting transepidermal water loss against stratum corneum thickness in man, shows that every layer in the stratum corneum acts as part of the epidermal barrier to water loss. Another function of the stratum corneum is to decrease the cutaneous penetration of topical corticosteroids like difluprednate and to modify their bioavailability ('corticosteroid reservoir'). Our data suggest that variations in stratum corneum thickness between subjects explain variation of transepidermal water loss and sensitivity difluprednate, as there is a close relationship between these two parameters. It is then conceivable than the phototype has clinical implications is there really exists a relationship between phototype, stratum corneum thickness and sensitivity to steroids.
通过绘制人体经表皮水分流失与角质层厚度的关系曲线，对实验曲线和理论曲线进行的对比研究表明，角质层中的每一层都作为表皮水分流失屏障的一部分发挥作用。角质层的另一个功能是降低局部皮质类固醇（如双氟泼尼酯）的皮肤渗透性，并改变其生物利用度（“皮质类固醇储存库”）。我们的数据表明，受试者之间角质层厚度的差异解释了经表皮水分流失和双氟泼尼酯敏感性的差异，因为这两个参数之间存在密切关系。因此可以设想，如果光型、角质层厚度和对类固醇的敏感性之间确实存在关系，那么光型就具有临床意义。
