Hess G, Arnold W, Hopf U, Witt D, Meyer zum Büschenfelde K H
Digestion. 1979;19(3):202-9. doi: 10.1159/000198345.
A study was undertaken to elucidate the etiology of HBsAg-negative chronic hepatitis. Form 37 individuals with HBsAg-negative chronic hepatitis, 11 had liver membrane autoantibody (LMA) and were thus classified as autoimmune. 6 patients had anti-HBc, 1 of which was also positive for LMA. The majority of individuals with HBsAg-negative chronic hepatitis had antibodies to hepatitis A antigen (anti-HAV), in general at low titer. We conclude from our data that hepatitis A and hepatitis B virus infections are unlikely to play a significant role in inducing or maintaining HBs-Ag-negative chronic hepatitis. The etiological role of non-A non-B hepatitis agent(s) is difficult to estimate and must await the detection of appropriate markers for type non-A non-B hepatitis.
开展了一项研究以阐明乙肝表面抗原（HBsAg）阴性慢性肝炎的病因。在37例HBsAg阴性慢性肝炎患者中，11例有肝细胞膜自身抗体（LMA），因此被归类为自身免疫性肝炎。6例患者有抗乙肝核心抗体（anti-HBc），其中1例LMA也呈阳性。大多数HBsAg阴性慢性肝炎患者有甲型肝炎抗原抗体（anti-HAV），一般滴度较低。我们从数据中得出结论，甲型肝炎病毒和乙型肝炎病毒感染在诱导或维持HBsAg阴性慢性肝炎方面不太可能起重要作用。非甲非乙型肝炎病原体的病因学作用难以估计，必须等待检测到合适的非甲非乙型肝炎标志物。
