慢性活动性肝炎中乙肝核心抗原抗体
Antibody to hepatitis B core antigen in chronic active hepatitis.
作者信息
Bories P, Coursaget P, Goudeau A, Degott C, Maupas P, Benhamou J P
出版信息
Br Med J. 1978 Feb 18;1(6110):396-7. doi: 10.1136/bmj.1.6110.396.
Abstract
Antibody to hepatitis B core antigen (anti-HBc), which has been assumed to be a more sensitive indicator of hepatitis B virus replication than hepatitis B surface antigen (HBsAg), was detected in the sera of 26 of our 65 patients with HBsAg-negative chronic active hepatitis. Thus despite the absence of HBsAg the liver disease could be the consequence of chronic infection with hepatitis B virus in these patients. They differed, however, from a group of 35 patients with HBsAg-positive hepatitis in being older on average and having less active liver lesions. The two groups could represent either two stages of chronic infection with hepatitis B virus or two types of response to it.
摘要
在我们65例乙肝表面抗原（HBsAg）阴性的慢性活动性肝炎患者中，有26例患者血清中检测到乙肝核心抗原抗体（抗-HBc），该抗体被认为是比乙肝表面抗原更敏感的乙肝病毒复制指标。因此，尽管这些患者没有HBsAg，但肝脏疾病仍可能是乙肝病毒慢性感染的结果。然而，他们与35例HBsAg阳性肝炎患者不同，平均年龄更大，肝脏病变活性更低。这两组患者可能代表乙肝病毒慢性感染的两个阶段，也可能代表对乙肝病毒的两种反应类型。
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本文引用的文献
1
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N Engl J Med. 1974 Jun 13;290(24):1336-40. doi: 10.1056/NEJM197406132902402.
2
Relationship of hepatitis-associated antigen (H.A.A.) to acute and chronic liver injury.肝炎相关抗原（H.A.A.）与急慢性肝损伤的关系。
Lancet. 1971 Jul 3;2(7714):1-3. doi: 10.1016/s0140-6736(71)90001-8.
3
Automated complement fixation test for the detection of antibodies against the core of hepatitis B virus (HBc).用于检测抗乙型肝炎病毒（HBc）核心抗体的自动化补体结合试验。
J Immunol Methods. 1976;13(1):21-7. doi: 10.1016/0022-1759(76)90183-6.
4
[The rate constant K37 in complement fixation tests: kinetic studies on the influenza virus-immune complex model (author's transl)].补体结合试验中的速率常数K37：流感病毒-免疫复合物模型的动力学研究（作者译）
Ann Microbiol (Paris). 1976 Aug-Sep;127B(2):269-79.
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