Taché Y, Du Ruisseau P, Ducharme J R, Collu R
Neuroendocrinology. 1978;26(4):208-19. doi: 10.1159/000122828.
To delineate the pattern of adenohypophyseal hormone secretion following chronic stress, adult male rats were exposed daily to 6 h of cold, forced exercise or immobilization for 3, 6, 10, 15, 28 or 42 consecutive days. Groups of these animals were sacrificed at the end of the last stress sessions, and plasma growth hormone (GH), luteinizing hormone (LH), prolactin (Prl) and follicle-stimulating hormone (FSH) levels were measured by radioimmunoassay (RIA). Irresspective of the different stimuli used, long-term stress induced a morphologic and hormonal response characterized by decreased ponderal growth, adrenal enlargement, thymus involution and significant diminutions in GH, Prl and LH levels with no modifications in FSH titers. The magnitude and duration of these changes varied with the severity of the stressors.
为了描绘慢性应激后腺垂体激素分泌的模式，成年雄性大鼠连续3、6、10、15、28或42天每天暴露于6小时的寒冷、强迫运动或固定应激环境中。在最后一次应激实验结束时处死这些动物的各个组，并通过放射免疫测定法（RIA）测量血浆生长激素（GH）、黄体生成素（LH）、催乳素（Prl）和促卵泡激素（FSH）水平。无论使用何种不同的刺激，长期应激均诱导了一种形态学和激素反应，其特征为体重增长减少、肾上腺增大、胸腺退化以及GH、Prl和LH水平显著降低，而FSH滴度无变化。这些变化的程度和持续时间随应激源的严重程度而变化。
