Du Ruisseau P, Taché Y, Selye H, Ducharme J R, Collu R
Neuroendocrinology. 1977;24(3-4):169-82. doi: 10.1159/000122707.
Morphologic and hormonal changes, induced by combined ablation of a thyroid lobe, one adrenal and one ovary, were studied over a 15-day period in rats, some of whom were subjected to 8 h of daily immobilization. The compensatory hypertrophy (CH) of the contralateral glands in non-stressed animals was associated with a significant increase in the plasma levels of LH (from the 1st to the 10th day), prolactin (PRL, from the 3rd to the 6th day), FSH (on the 3rd day) and corticosterone (from the 6th to the 15th day), whereas GH titers were not altered. Immobilization for 1, 3, 6, 10 or 15 days inhibited the b.w. gain, induced involution of the thymus, enhanced compensatory enlargement of the adrenal, and blocked the CH of the ovary and, to a lesser degree, of the thyroid. This chronic stressor produced a marked rise in plasma corticosterone, antagonized the surge of PRL, FSH and LH, and decreased the plasma levels of GH. On the basis of these morphological and hormonal variations, it appears that severe chronic stress in hemi-thyroidectomized-adrenalectomized-ovariectomized animals further increases the ACTH response but antagonizes the increased secretion of the other pituitary hormones.
在大鼠中，研究了甲状腺叶、一侧肾上腺和一侧卵巢联合切除所诱导的形态学和激素变化，为期15天，其中一些大鼠每天固定8小时。非应激动物对侧腺体的代偿性肥大（CH）与血浆中LH水平（第1天至第10天）、催乳素（PRL，第3天至第6天）、FSH（第3天）和皮质酮（第6天至第15天）的显著升高相关，而生长激素水平未改变。固定1、3、6、10或15天会抑制体重增加，导致胸腺退化，增强肾上腺的代偿性增大，并阻断卵巢的CH，对甲状腺的CH阻断程度较小。这种慢性应激源使血浆皮质酮显著升高，拮抗PRL、FSH和LH的激增，并降低血浆生长激素水平。基于这些形态学和激素变化，似乎半甲状腺切除-肾上腺切除-卵巢切除动物的严重慢性应激会进一步增加促肾上腺皮质激素反应，但拮抗其他垂体激素的分泌增加。
