Ruisseau P D, Taché Y, Brazeau P, Collu R
Neuroendocrinology. 1978;27(5-6):257-71. doi: 10.1159/000122818.
Plasma modifications of adenohypophyseal hormones were investigated in groups of female and male rats stressed for 15, 30 min, 1, 2, 4 or 6 h, either by cold (4 degrees C), forced muscular exercise (FME), or immobilization. GH levels in both female and male rats were consistently decreased by the 3 stressing agents. Immobilization in the female and the 3 stressors in the male elicited an early secretory response of prolactin (Prl), while only in immobilized female rats plasma LH levels showed an early, short-lived increment. A more prolonged exposure to stress had an inhibitory influence on plasma Prl and LH levels in both sexes. FSH concentrations were not modified in females, but were decreased in male rats submitted to either one of the 3 stressors. In both male and female rats plasma TSH levels rose during cold exposure, while they were decreased by FME and by immobilization. Our data indicate that the character of the hormonal secretory response during stress is nonspecific. Indeed, to the exception of the specific stimulation of TSH release by cold, stress-induced hormonal changes are not related to the nature but rather to the intensity and duration of the stressing agent.
对雌性和雄性大鼠进行研究，观察冷刺激（4摄氏度）、强迫肌肉运动（FME）或固定等应激处理15分钟、30分钟、1小时、2小时、4小时或6小时后腺垂体激素的血浆变化。三种应激因素均使雌性和雄性大鼠的生长激素（GH）水平持续下降。雌性大鼠固定以及雄性大鼠的三种应激因素均引发催乳素（Prl）的早期分泌反应，而仅在固定的雌性大鼠中，血浆促黄体生成素（LH）水平出现早期、短暂的升高。长时间暴露于应激对两性的血浆Prl和LH水平均有抑制作用。雌性大鼠的促卵泡生成素（FSH）浓度未改变，但接受三种应激因素之一的雄性大鼠FSH浓度降低。在雌性和雄性大鼠中，冷暴露期间血浆促甲状腺激素（TSH）水平升高，而FME和固定则使其降低。我们的数据表明，应激期间激素分泌反应的特征是非特异性的。实际上，除了冷刺激对TSH释放的特异性刺激外，应激诱导的激素变化与应激因素的性质无关，而与应激因素的强度和持续时间有关。
