多发性硬化症中的锌和铜
Zinc and copper in multiple sclerosis.
作者信息
Palm R, Hallmans G
出版信息
J Neurol Neurosurg Psychiatry. 1982 Aug;45(8):691-8. doi: 10.1136/jnnp.45.8.691.
Abstract
The serum concentrations of zinc and copper were measured in 50 patients with multiple sclerosis. Lower serum zinc levels were found compared to age- and sex-matched controls. In younger patients low serum copper concentrations were noted. Zinc concentrations in CSF were unchanged. The possibility that malabsorption of the metals causes the low serum concentrations is discussed.
摘要
对50例多发性硬化症患者的血清锌和铜浓度进行了测量。与年龄和性别匹配的对照组相比，发现血清锌水平较低。在较年轻的患者中，血清铜浓度较低。脑脊液中的锌浓度没有变化。讨论了金属吸收不良导致血清浓度降低的可能性。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Experimental zinc deficiency and recovery of calves.犊牛的实验性锌缺乏与恢复
J Nutr. 1962 Apr;76:467-74. doi: 10.1093/jn/76.4.467.
3
ABSORPTION OF COPPER IN MALABSORPTION SYNDROMES.吸收不良综合征中铜的吸收
J Clin Invest. 1964 Jun;43(6):1049-55. doi: 10.1172/JCI104988.
4
Studies on variations in serum copper and serum copper oxidase activity, together with studies on the copper content of the cerebrospinal fluid, with particular reference to the variations in multiple sclerosis.关于血清铜及血清铜氧化酶活性变化的研究，以及关于脑脊液铜含量的研究，尤其涉及多发性硬化症中的变化。
Acta Psychiatr Scand Suppl. 1960;35(148):41-78. doi: 10.1111/j.1600-0447.1960.tb08680.x.
5
[Blood protein picture in multiple sclerosis].[多发性硬化症中的血液蛋白图谱]
Wien Z Nervenheilkd Grenzgeb. 1956;13(1-2):46-64.
6
Electrophoresis of sera in multiple sclerosis and other neurological diseases.多发性硬化症及其他神经系统疾病患者血清的电泳分析
J Neurol Neurosurg Psychiatry. 1956 Aug;19(3):222-3. doi: 10.1136/jnnp.19.3.222.
7
Protein profile in multiple sclerosis.多发性硬化症中的蛋白质谱
AMA Arch Neurol Psychiatry. 1955 Jan;73(1):66-75. doi: 10.1001/archneurpsyc.1955.02330070068009.
8
Plasma zinc levels in multiple sclerosis.多发性硬化症患者的血浆锌水平
Metab Pediatr Ophthalmol. 1980;4(1):3-8.
9
Comprehensive viral immunology of multiple sclerosis. I. Clinical, epidemiological, and CSF studies.多发性硬化症的综合病毒免疫学。I. 临床、流行病学及脑脊液研究。
Arch Neurol. 1980 Sep;37(9):537-41. doi: 10.1001/archneur.1980.00500580033003.
10
Determination of zinc in serum and urine by atomic absorption spectrophotometry; relationship between serum levels of zinc and proteins in 104 normal subjects.
Clin Chim Acta. 1980 Aug 4;105(2):231-9. doi: 10.1016/0009-8981(80)90465-9.
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