炎症性直肠黏膜的筛检特征
Sieving characteristics of inflamed rectal mucosa.
作者信息
Rask-Madsen J
出版信息
Gut. 1973 Dec;14(12):988-9. doi: 10.1136/gut.14.12.988.
Abstract
The sieving characteristics of the normal and inflamed rectal mucosa are studied in three healthy volunteers and five patients with ulcerative colitis. Following rectal instillation of (125)I-polyvinylpyrrolidone (PVP), the molecular size distribution of labelled PVP in urine samples was determined by Sephadex gel filtration. The results of the study suggest that the increased permeability of the inflamed rectal mucosa to electrolytes and small hydrophilic compounds is due primarily to ultrastructural changes since only the low molecular fractions of PVP were found in the urine.
摘要
在三名健康志愿者和五名溃疡性结肠炎患者中研究了正常和发炎直肠黏膜的筛分特性。经直肠注入碘-125标记的聚乙烯吡咯烷酮（PVP）后，通过葡聚糖凝胶过滤法测定尿液样本中标记PVP的分子大小分布。研究结果表明，发炎直肠黏膜对电解质和小分子亲水性化合物通透性增加主要是由于超微结构变化，因为尿液中仅发现了低分子部分的PVP。
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The relationship between sodium fluxes and electrical potentials across the normal and inflamed human rectal wall in vivo.体内正常及发炎的人体直肠壁上钠通量与电势之间的关系。
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6
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