在经环氧乙烷灭菌的聚碳酸酯培养瓶中生长对L5178Y小鼠淋巴瘤细胞的诱变作用。
Mutagenic effect on L5178Y mouse lymphoma cells by growth in ethylene oxide-sterilized polycarbonate flasks.
作者信息
Krell K, Jacobson E D, Selby K
出版信息
In Vitro. 1979 May;15(5):326-8. doi: 10.1007/BF02616138.
PMID:478562
Abstract
The mutation frequency of L5178Y mouse lymphoma cells to resistance to 5'-bromo-2'-deoxyuridine increased 6- to 14-fold after growth in ethylene oxide-sterilized polycarbonate culture flasks compared to growth in glass flasks. No comparable increase was observed when L5178Y cells were grown in identical polycarbonate culture flasks sterilized by autoclaving.
摘要
与在玻璃培养瓶中生长相比，L5178Y小鼠淋巴瘤细胞对5'-溴-2'-脱氧尿苷产生抗性的突变频率在环氧乙烷灭菌的聚碳酸酯培养瓶中生长后增加了6至14倍。当L5178Y细胞在通过高压灭菌法灭菌的相同聚碳酸酯培养瓶中生长时，未观察到类似的增加。
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