Large B J, Wright J L
Br J Pharmacol. 1973 Dec;49(4):702-5. doi: 10.1111/j.1476-5381.1973.tb08548.x.
Superfused segments of mouse ileum exhibited spontaneous movement which Mwere inhibited by sympathomimetic amines. Isoprenaline and adrenaline were approximately equipotent and about 15 times more potent than either noradrenaline or phenylephrine. Supersensitivity developed to all these agents when mice had been 'sympathectomized' with NGF-antiserum or 6-hydroxydopamine and it was more pronounced with the latter treatment. Responses to the amines were reduced by phentolamine and propranolol, alone or in combination, with the exception of phenylephrine, the responses to which were simply shortened in duration after,beta-adrenoceptor blockade. No qualitative changes were evident in the effects of the blocking agents after 'sympathectomy'.
小鼠回肠的灌流节段呈现出自发运动，该运动受到拟交感胺的抑制。异丙肾上腺素和肾上腺素的效力大致相当，且比去甲肾上腺素或去氧肾上腺素的效力约强15倍。当用神经生长因子抗血清或6-羟基多巴胺对小鼠进行“交感神经切除”后，对所有这些药物均产生了超敏反应，且后一种处理方式下更为明显。酚妥拉明和普萘洛尔单独或联合使用时，对胺类药物的反应均降低，但去氧肾上腺素除外，β-肾上腺素能受体阻断后，其反应仅持续时间缩短。“交感神经切除”后，阻断剂的作用未出现明显的质性变化。
