急性呼吸道感染期间痰液中的头孢氨苄浓度。
Cephalexin concentrations in sputum during acute respiratory infections.
作者信息
Halprin G M, McMahon S M
出版信息
Antimicrob Agents Chemother. 1973 Jun;3(6):703-7. doi: 10.1128/AAC.3.6.703.
Abstract
In 20 patients with acute pulmonary infections, sputum purulence, sputum volume, and concentration and excretion of cephalexin in the sputum significantly decreased concurrently during therapy. The concentration of cephalexin in the serum remained unchanged. Significant correlations were observed between drug concentrations in sputum and serum and between drug excretion in sputum and concentration in serum. These observations may be explained by decreased integrity of the "blood-bronchus barrier" during inflammation, with diffusion of serum into bronchial mucus, without the necessity of postulating active transport.
摘要
在20例急性肺部感染患者中，治疗期间痰液脓性、痰量以及痰液中头孢氨苄的浓度和排泄量同时显著下降。血清中头孢氨苄的浓度保持不变。痰液和血清中的药物浓度之间以及痰液中的药物排泄量和血清中的浓度之间观察到显著相关性。这些观察结果可以通过炎症期间“血-支气管屏障”完整性降低，血清扩散到支气管黏液中，而无需假定主动转运来解释。
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