Tanira M O, Ali B H, Bashir A K, Wasfi I A, Chandranath I
Department of Pharmacology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain.
J Pharm Pharmacol. 1996 May;48(5):545-50. doi: 10.1111/j.2042-7158.1996.tb05971.x.
Although medicinal plants are used as antispasmodic agents in folk medicine there have been no scientific studies of the phytochemical composition and usefulness of these plants for such treatment. Extracts of 23 plants used in the traditional medicine of the United Arab Emirates were tested for their effects on intestinal smooth muscle activity. Most of the plants tested caused stimulation followed by inhibition of the motility of the rabbit jejunum and guinea-pig ileum. The inhibitory effect of plants that had EC50 values < 1 mg was confirmed in-vivo using the gastrointestinal transit time test. These plants were phytochemically screened for their secondary constituents. The effect of Rhazya stricta was investigated, particularly in relation to acetylcholine effect. The results indicated the potential of some of the plants, especially Rhazya stricta, as a source of antispasmodic agents.
尽管药用植物在民间医学中被用作解痉剂，但尚未对这些植物的植物化学成分及其在这种治疗中的效用进行科学研究。对阿拉伯联合酋长国传统医学中使用的23种植物提取物进行了测试，以观察它们对肠道平滑肌活动的影响。大多数受试植物先是引起兔空肠和豚鼠回肠运动的刺激，随后是抑制。使用胃肠转运时间试验在体内证实了EC50值<1毫克的植物的抑制作用。对这些植物的次生成分进行了植物化学筛选。研究了刺山柑（Rhazya stricta）的作用，特别是与乙酰胆碱作用相关的作用。结果表明，一些植物，特别是刺山柑，有可能作为解痉剂的来源。
