Tickle C, Crawley A, Roscoe J P
J Cell Sci. 1979 Jun;37:143-56. doi: 10.1242/jcs.37.1.143.
Cells from normal rat brain tissue did not survive and few cells could be found 1 d after grafting. In contrast, cells from a glioma and a carcinogen-treated rat brain survived well and many mitoses were observed. These malignant cells also invaded the limb. The behaviour of normal and malignant cells was followed at shorter times after grafting and some invasion by the normal cells was detected. The first signs of degeneration of normal cells were apparent around 7 h after grafting, and after this the grafts progressively deteriorated. These results support the ideal that the ability of cells to survive and grow in embryonic tissues is a characteristic of malignant cells. The findings are discussed in relation to mechanisms of tumour formation.
来自正常大鼠脑组织的细胞无法存活，移植1天后几乎找不到细胞。相比之下，来自神经胶质瘤和经致癌物处理的大鼠脑组织的细胞存活良好，并且观察到许多有丝分裂。这些恶性细胞还侵入了肢体。在移植后较短时间内跟踪正常细胞和恶性细胞的行为，发现正常细胞有一些侵袭现象。正常细胞退化的最初迹象在移植后约7小时明显出现，此后移植物逐渐恶化。这些结果支持了这样一种观点，即细胞在胚胎组织中存活和生长的能力是恶性细胞的一个特征。结合肿瘤形成机制对这些发现进行了讨论。
