• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

伏隔核局部损伤对C57BL/6J小鼠吗啡和苯丙胺诱导的运动性活动亢进的不同影响。

Differential effects of localized lesions of n. accumbens on morphine- and amphetamine-induced locomotor hyperactivity in the C57BL/6J mouse.

作者信息

Teitelbaum H, Giammatteo P, Mickley G A

出版信息

J Comp Physiol Psychol. 1979 Aug;93(4):745-51. doi: 10.1037/h0077605.

DOI:10.1037/h0077605
PMID:479406
Abstract

Mice of the C57BL/6J strain became hyperactive to increasing doses of morphine sulfate. This response was similar to locomotor hyperactivity induced by amphetamine. Lesions and chemical blockade of posterior n. accumbens abolished amphetamine-induced hyperactivity and reduced but did not abolish the morphine response. These experiments demonstrate that the response to the two drugs is mediated by overlapping but noncongruent neural systems.

摘要

C57BL/6J品系的小鼠对递增剂量的硫酸吗啡变得多动。这种反应类似于苯丙胺诱导的运动性多动。伏隔核后部的损伤和化学阻断消除了苯丙胺诱导的多动，并减弱了但并未消除吗啡反应。这些实验表明，对这两种药物的反应是由重叠但不完全相同的神经系统介导的。

相似文献

1
Differential effects of localized lesions of n. accumbens on morphine- and amphetamine-induced locomotor hyperactivity in the C57BL/6J mouse.伏隔核局部损伤对C57BL/6J小鼠吗啡和苯丙胺诱导的运动性活动亢进的不同影响。
J Comp Physiol Psychol. 1979 Aug;93(4):745-51. doi: 10.1037/h0077605.
2
Brain areas involved in production of morphine-induced locomotor hyperactivity of the C57B1/6J mouse.
Pharmacol Biochem Behav. 1986 Jun;24(6):1739-47. doi: 10.1016/0091-3057(86)90514-9.
3
Locomotor activation induced by MK-801 in the rat: postsynaptic interactions with dopamine receptors in the ventral striatum.MK-801诱导大鼠的运动激活：与腹侧纹状体中多巴胺受体的突触后相互作用
Eur J Pharmacol. 1994 Jan 14;251(2-3):229-36. doi: 10.1016/0014-2999(94)90404-9.
4
A role for the mesolimbic dopamine system in the psychostimulant actions of MDMA.中脑边缘多巴胺系统在摇头丸精神刺激作用中的作用。
Psychopharmacology (Berl). 1989;99(1):40-7. doi: 10.1007/BF00634450.
5
A comparison of the effects of intra-accumbens injections of amphetamine and morphine on reinstatement of heroin intravenous self-administration behavior.伏隔核内注射苯丙胺和吗啡对海洛因静脉自身给药行为恢复影响的比较。
Brain Res. 1988 Aug 9;457(2):287-94. doi: 10.1016/0006-8993(88)90698-1.
6
Histamine H2 receptors mediate morphine-induced locomotor hyperactivity of the C57BL/6J mouse.组胺H2受体介导吗啡诱导的C57BL/6J小鼠运动性亢进。
Behav Neurosci. 1986 Feb;100(1):79-84. doi: 10.1037//0735-7044.100.1.79.
7
Amphetamine administered to the ventral tegmental area but not to the nucleus accumbens sensitizes rats to systemic morphine: lack of conditioned effects.向腹侧被盖区而非伏隔核注射苯丙胺会使大鼠对全身注射吗啡敏感：缺乏条件性效应。
Brain Res. 1990 May 14;516(1):99-106. doi: 10.1016/0006-8993(90)90902-n.
8
Association of the mesencephalic locomotor region with locomotor activity induced by injections of amphetamine into the nucleus accumbens.中脑运动区与向伏隔核注射苯丙胺所诱导的运动活动之间的关联。
Brain Res. 1985 May 13;334(1):77-84. doi: 10.1016/0006-8993(85)90569-4.
9
Effects of amphetamine and apomorphine on locomotor activity after kainic acid lesion of the nucleus accumbens septi in the rat.苯丙胺和阿扑吗啡对大鼠伏隔核海人藻酸损伤后运动活动的影响。
Psychopharmacology (Berl). 1986;88(3):271-4. doi: 10.1007/BF00180823.
10
Drug-induced place preference in rats with 5,7-dihydroxytryptamine lesions of the nucleus accumbens.
Behav Brain Res. 1988 Jul;29(1-2):127-34. doi: 10.1016/0166-4328(88)90060-5.

引用本文的文献

1
Effects of the selective dopamine D receptor antagonist PG01037 on morphine-induced hyperactivity and antinociception in mice.选择性多巴胺 D 受体拮抗剂 PG01037 对吗啡诱导的小鼠活动亢进和镇痛作用的影响。
Behav Brain Res. 2021 Oct 11;415:113506. doi: 10.1016/j.bbr.2021.113506. Epub 2021 Aug 2.
2
Heteromers of μ opioid and dopamine D receptors modulate opioid-induced locomotor sensitization in a dopamine-independent manner.μ 阿片受体和多巴胺 D 受体的异源二聚体以多巴胺非依赖的方式调节阿片诱导的运动敏化。
Br J Pharmacol. 2017 Sep;174(17):2842-2861. doi: 10.1111/bph.13908. Epub 2017 Jul 18.
3
Targeting pain-depressed behaviors in preclinical assays of pain and analgesia: drug effects on acetic acid-depressed locomotor activity in ICR mice.
在疼痛与镇痛的临床前试验中针对疼痛抑制行为：药物对ICR小鼠醋酸诱导的运动活动抑制的影响
Life Sci. 2009 Aug 12;85(7-8):309-15. doi: 10.1016/j.lfs.2009.06.006. Epub 2009 Jun 24.
4
Effect of adrenalectomy and corticosterone replacement on prepulse inhibition and locomotor activity in mice.肾上腺切除术及皮质酮替代对小鼠前脉冲抑制和运动活动的影响。
Br J Pharmacol. 2004 Jun;142(3):543-50. doi: 10.1038/sj.bjp.0705511. Epub 2004 May 17.
5
Interval-dependent inhibition of morphine sensitization of ambulation in mice by post-morphine treatment with naloxone or restraint.吗啡处理后用纳洛酮或进行束缚对小鼠行走中吗啡敏化的间隔依赖性抑制。
Psychopharmacology (Berl). 1996 May;125(2):129-34. doi: 10.1007/BF02249411.
6
The effects of radio-frequency lesions of the nucleus accumbens on d-amphetamine-induced locomotor and rearing behavior in rats.
Psychopharmacology (Berl). 1981;75(4):363-7. doi: 10.1007/BF00435854.
7
Differential effects of opiate agonists-antagonists on morphine-induced hyperexcitability and analgesia in mice.阿片类激动剂-拮抗剂对小鼠吗啡诱导的过度兴奋和镇痛的不同作用。
Psychopharmacology (Berl). 1981;73(2):134-6. doi: 10.1007/BF00429203.
8
Chronic morphine-induced hyperactivity in rats is altered by nucleus accumbens and ventral tegmental lesions.
Psychopharmacology (Berl). 1984;82(4):318-21. doi: 10.1007/BF00427677.
9
Brain mu and delta opioid receptors mediate different locomotor hyperactivity responses of the C57BL/6J mouse.
Psychopharmacology (Berl). 1990;101(3):332-7. doi: 10.1007/BF02244050.
10
Electrolytic lesions of the nucleus accumbens in rats which abolish the PREE enhance the locomotor response to amphetamine.消除先前提早反应效应（PREE）的大鼠伏隔核电解损伤增强了对苯丙胺的运动反应。
Exp Brain Res. 1991;86(2):333-40. doi: 10.1007/BF00228956.