Filibeck U, Castellano C, Oliverio A
Psychopharmacology (Berl). 1981;73(2):134-6. doi: 10.1007/BF00429203.
The effects of two opiate agonists-antagonists, butorphanol (4.0 and 8.0 mg/kg) and buprenorphine (0.1 and 1.0 mg/kg), were assessed on locomotor activity and analgesia in DBA/2 and C57BL/6 mice. Different behavioral effects were evident in these strains, which might be characterized by different reactions to the effects of opiates and by differences in endorphin distributions and opiate receptor populations. In particular, buprenorphine acted as an agonist-antagonist to morphine in both strains while a dissociation of butorphanol effects was evident, depending on the strain considered. The clinical implications of these findings are discussed.
评估了两种阿片类激动剂 - 拮抗剂布托啡诺（4.0 和 8.0 毫克/千克）和丁丙诺啡（0.1 和 1.0 毫克/千克）对 DBA/2 和 C57BL/6 小鼠运动活性和镇痛作用的影响。在这些品系中观察到了不同的行为效应，这可能表现为对阿片类药物作用的不同反应以及内啡肽分布和阿片受体数量的差异。特别是，丁丙诺啡在两种品系中对吗啡均表现为激动 - 拮抗剂作用，而布托啡诺的效应则明显不同，这取决于所考虑的品系。讨论了这些发现的临床意义。
