Weisz-Carrington P, Roux M E, McWilliams M, PHILLIPS-Quagliata J M, Lamm M E
J Immunol. 1979 Oct;123(4):1705-8.
Mice were induced to produce IgA antibodies against ferritin after oral immunization. Such antibodies were detected by immunofluorescence in plasma cells in the intestinal mucosa as well as in secretory sites located elsewhere, such as the lactating mammary gland, salivary gland, and respiratory tract. The observation suggested that cells immunized locally via the gut could home to distant secretory sites. To confirm this hypothesis, lymphocyte transfer studies were done with mesenteric node (MN) versus peripheral node (PN) cells from orally immunized donors into nonimmunized recipients. IgA anti-ferritin cells from MN homed to exocrine targets, whereas IgM and IgG anti-ferritin cells homed to PN. The findings overall support the concept of a generalized and interrelated secretory immune system.
经口服免疫后，诱导小鼠产生针对铁蛋白的IgA抗体。通过免疫荧光法在肠黏膜浆细胞以及其他分泌部位（如泌乳乳腺、唾液腺和呼吸道）检测到此类抗体。该观察结果表明，经肠道局部免疫的细胞可归巢至远处的分泌部位。为证实这一假设，进行了淋巴细胞转移研究，即将来自经口服免疫供体的肠系膜淋巴结（MN）细胞与外周淋巴结（PN）细胞转移至未免疫的受体体内。来自MN的IgA抗铁蛋白细胞归巢至外分泌靶器官，而IgM和IgG抗铁蛋白细胞归巢至PN。这些发现总体上支持了广义且相互关联的分泌免疫系统的概念。
