Heck H A, Buttrill S E, Flynn N W, Dyer R L, Anbar M, Cairns T, Dighe S, Cabana B E
J Pharmacokinet Biopharm. 1979 Jun;7(3):233-48. doi: 10.1007/BF01060015.
A new methodology for comparative bioavailability testing is described in which each drug formulation is compared with a stable isotope-labeled variant of the drug that is consumed orally in solution at the same time the tested formulation is ingested. The methodology is used to determine the comparative bioavailabilities of two commercially available brands of imipramine hydrochloride. The power of the new methodology to detect differences between drug formulations, when, in fact, such differences exist, is shown to be superior to that of conventional bioavailability tests.
本文描述了一种用于比较生物利用度测试的新方法，其中每种药物制剂都与该药物的稳定同位素标记变体进行比较，该变体在摄入受试制剂的同时以溶液形式口服。该方法用于测定两种市售品牌盐酸丙咪嗪的相对生物利用度。结果表明，当药物制剂之间确实存在差异时，这种新方法检测差异的能力优于传统生物利用度测试。
