Apuzzo M L, Sheikh K M, Weiss M H, Heiden J S, Kurze T
Acta Neurochir (Wien). 1981;55(3-4):181-200. doi: 10.1007/BF01808436.
Cellular and humoral components of the immune response have been studied preoperatively, concurrently, and serially in patients with malignant glial neoplasms. In order to assess titres of circulating antibodies to tumour cell constituents an indirect immunofluorescent technique was applied to single cell suspensions and snap frozen cell smears. In an allogeneic system, 49% of 47 test and 7% of 124 control sera gave a positive response to cytoplasmic components. The leucocyte adherence inhibition assay was applied to study 39 test and 64 control patients. Significant non-adherence of leukocytes was observed in 77% of test cases. Control parameters indicated specificity of the response. Simultaneous assessment in 28 test patients yielded a positive response for one or both assays in 89% of cases..
已对恶性胶质肿瘤患者术前、术中及术后的免疫反应细胞和体液成分进行了研究。为了评估针对肿瘤细胞成分的循环抗体滴度，将间接免疫荧光技术应用于单细胞悬液和速冻细胞涂片。在同种异体系统中，47份测试血清中的49%以及124份对照血清中的7%对细胞质成分呈阳性反应。采用白细胞黏附抑制试验对39例测试患者和64例对照患者进行研究。在77%的测试病例中观察到白细胞明显不黏附。对照参数表明该反应具有特异性。对28例测试患者同时进行评估，结果显示89%的病例中一项或两项检测呈阳性反应。
