在磺胺异恶唑存在的情况下，慢性肉芽肿病患者吞噬细胞的杀菌活性增强。
Enhanced bactericidal activity of phagocytes from patients with chronic granulomatous disease in the presence of sulphisoxazole.
作者信息
Johnston R B, Wilfert C M, Buckley R H, Webb L S, DcChatelet L R, McCall C E
出版信息
Lancet. 1975 Apr 12;1(7911):824-7. doi: 10.1016/s0140-6736(75)93002-0.
The decrease in the frequency and severity of bacterial infections in four of five children with chronic granulomatous disease (C.G.D.) on long-term sulphonamide therapy was out of proportion to demonstrable direct antibacterial effects of the drug. In an attempt to determine the mechanism for this apparent protective effect, the killing of sulphisoxazole-resistant Escherichia coli and Staphylococcus aureus by leucocytes from five patients with C.G.D. was studied in the presence or absence of 5-50 mug. per ml. sulphisoxazole. With leucocytes from all five patients there was a modest but reproducible enhancement of bactericidal activity in the presence of the sulphonamide. Studies of phagocytosis-associated oxidative metabolism in patients' cell have not revealed a metabolic basis for improved killing.
五名患有慢性肉芽肿病（C.G.D.）的儿童中，有四名在接受长期磺胺治疗后，细菌感染的频率和严重程度有所降低，这与该药物明显的直接抗菌作用不成比例。为了确定这种明显保护作用的机制，研究了在有或没有每毫升5 - 50微克磺胺异恶唑存在的情况下，五名C.G.D.患者的白细胞对耐磺胺异恶唑的大肠杆菌和金黄色葡萄球菌的杀伤情况。在所有五名患者的白细胞中，磺胺存在时杀菌活性有适度但可重复的增强。对患者细胞中与吞噬作用相关的氧化代谢的研究尚未揭示出杀伤改善的代谢基础。
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