Chalon J, Katz J S, Ramanathan S, Ambiavagar M, Orkin L R
Science. 1974 Feb 8;183(4124):525-6. doi: 10.1126/science.183.4124.525.
Multinucleated tracheobronchial ciliated epithelial cells seen in smears from 112 patients suffering from a wide variety of malignant tumors were found to be 2.08 times more numerous than in a control group comparable in sex, age (decades), and smoking habit but without prediagnosed malignancies. The recognition of this phenomenon may lead to the development of a new test for the diagnosis of occult cancer and may open new pathways for investigation of cancer-host relationships.
在112例患有各种恶性肿瘤患者的涂片样本中发现，多核气管支气管纤毛上皮细胞数量比在性别、年龄（以十年计）和吸烟习惯相当但未预先诊断出恶性肿瘤的对照组中多2.08倍。认识到这一现象可能会促成一种用于诊断隐匿性癌症的新检测方法的开发，并可能为研究癌症与宿主关系开辟新途径。
