Chalon J, Katz J S, Gorstein F, Turndorf H
Cancer. 1976 Apr;37(4):1874-81. doi: 10.1002/1097-0142(197604)37:4<1874::aid-cncr2820370436>3.0.co;2-0.
Multinucleation of noncancerous ciliated tracheobronchial epithelial cells seen in smears from 412 patients suffering from malignant tumors originating from a wide variety of organs was found to be 2.03 times more frequent than in a control group without prediagnosed malignant disease, matched by age (decades), sex, and smoking habit (p less than 0.0005). Multinucleation involving at least 3% of cells was seen four times more frequently in patients with invasive tumors without known metastases than in controls. Excessive smoking habit in control females as well as site of origin and stage of tumor influenced statistical significance, otherwise unaffected by age, sex, and smoking habit in males. A prospective study is being planned in which incidence and degree of tracheobronchial epithelial multinucleation will be used in conjunction with biochemical tests for the diagnosis of occult cancer.
在412例患有源自多种器官的恶性肿瘤患者的涂片样本中，非癌性纤毛气管支气管上皮细胞的多核化现象被发现比年龄、性别和吸烟习惯相匹配的未被预先诊断出患有恶性疾病的对照组高出2.03倍（p小于0.0005）。在无已知转移的浸润性肿瘤患者中，至少3%的细胞出现多核化现象的频率是对照组的四倍。对照组女性的过度吸烟习惯以及肿瘤的起源部位和分期影响了统计显著性，而男性的年龄、性别和吸烟习惯则无此影响。正在计划进行一项前瞻性研究，其中气管支气管上皮多核化的发生率和程度将与生化检测结合用于隐匿性癌症的诊断。
