Chalon J, Turndorf H, Katz J S, Rand P B
J Reprod Med. 1977 Sep;19(3):141-6.
Patients with malignant disease are known to have an increased incidence of multinucleation in their tracheobronchial ciliated epithelial cells as compared with controls matched by age, sex and smoking habit. A seasonal relationship of viral inclusion bodies in the cilated epithelium of asymptomatic subjects has also been shown and is not related to age, sex and smoking habit. We have conducted an epidemiologic study to determine the possible relationships between these factors. Smears from 4,150 patients with a wide variety of pathologic conditions were examined for the presence of viral inclusions and multinucleated, ciliated epithelial cells. High degress of multinucleation were observed least frequenctly in the summer both in patients with and without known malignancy. Cytoplasmic inclusion bodies were also seen least frequently in the summer and autumn both in patients with and without know malignancy. In the presence of cancer, multinucleated epithelial cells and inclusion bodies were seen more frequently regardless of the season. When the seasonal incidence of multinucleated cells in 155 smears containing viral inclusion bodies was analyzed, it was found that patients without cancer had the lowest levels of multinucleation in the summer, whereas cancer patients had a depressed incidence of multinucleation in the winter and spring. Respiratory viruses may have a specific effect on the ciliated epithelium of cancer patients.
与年龄、性别和吸烟习惯相匹配的对照组相比，已知恶性疾病患者气管支气管纤毛上皮细胞中的多核化发生率更高。无症状受试者纤毛上皮细胞中的病毒包涵体也呈现出季节性关系，且与年龄、性别和吸烟习惯无关。我们开展了一项流行病学研究，以确定这些因素之间可能存在的关系。对4150例患有各种病理状况的患者涂片进行检查，以确定是否存在病毒包涵体和多核纤毛上皮细胞。无论是患有还是未患有已知恶性肿瘤的患者，夏季观察到的多核化程度最低。无论是患有还是未患有已知恶性肿瘤的患者，细胞质包涵体在夏季和秋季也最少见。在患有癌症的情况下，无论季节如何，多核上皮细胞和包涵体更常见。当分析155份含有病毒包涵体的涂片中多核细胞的季节性发生率时，发现无癌症患者在夏季的多核化水平最低，而癌症患者在冬季和春季的多核化发生率较低。呼吸道病毒可能对癌症患者的纤毛上皮细胞有特定影响。
