一种简单而精确的胆固醇向孕烯醇酮酶促转化测定法。 - Suppr

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A simple and precise assay of the enzymatic conversion of cholesterol into pregnenolone.

作者信息

Hochberg R B, Welch M, Lieberman S

出版信息

Biochemistry. 1974 Jan 29;13(3):603-9. doi: 10.1021/bi00700a031.

DOI:10.1021/bi00700a031

PMID:4810069

Abstract

摘要

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A simple and precise assay of the enzymatic conversion of cholesterol into pregnenolone.一种简单而精确的胆固醇向孕烯醇酮酶促转化测定法。

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Cholesterol and cholesterol sulfate as substrates for the adrenal side-chain cleavage enzyme.

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Cytochrome P-450 from bovine adrenocortical mitochondria: an enzyme for the side chain cleavage of cholesterol. I. Purification and properties.来自牛肾上腺皮质线粒体的细胞色素P-450：一种参与胆固醇侧链裂解的酶。I. 纯化及性质

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Enzymatic side chain cleavage of C-20 alkyl and aryl analogs of (20-S)-20-hydroxycholesterol. Implications for the biosynthesis of pregnenolone.（20-S）-20-羟基胆固醇的C-20烷基和芳基类似物的酶促侧链裂解。对孕烯醇酮生物合成的影响。

J Biol Chem. 1979 Apr 10;254(7):2278-86.

Studies on the biosynthetic conversion of cholesterol into pregnenolone. Side chain cleavage of some 20-p-tolyl analogs of cholesterol and 20 alpha-hydroxycholesterol.

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Cofactor requirements for the conversion of cholesterol sulfate to pregnenolone sulfate by a submitochondrial system from bovine adrenal ortex.牛肾上腺皮质亚线粒体系统将硫酸胆固醇转化为硫酸孕烯醇酮所需的辅助因子。

Biochem Biophys Res Commun. 1968 Jun 28;31(6):925-31. doi: 10.1016/0006-291x(68)90541-x.

Kinetic studies on the mechanism of conversion of cholesterol to pregnenolone.胆固醇转化为孕烯醇酮机制的动力学研究。

Ann N Y Acad Sci. 1973;212:262-75. doi: 10.1111/j.1749-6632.1973.tb47601.x.

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Front Pharmacol. 2018 Sep 12;9:1027. doi: 10.3389/fphar.2018.01027. eCollection 2018.

Unreliability of tritiated cholesterol: studies with [1,2-3H]-cholesterol and [24,25-3H]cholesterol in humans.氚标记胆固醇的不可靠性：[1,2-³H] -胆固醇和[24,25-³H] -胆固醇在人体中的研究

Proc Natl Acad Sci U S A. 1980 Apr;77(4):2255-9. doi: 10.1073/pnas.77.4.2255.

Modulation of the kinetics of cholesterol side-chain cleavage by an activator and by an inhibitor isolated from the cytosol of the cortex of bovine adrenals.一种激活剂和一种从牛肾上腺皮质细胞质中分离出的抑制剂对胆固醇侧链裂解动力学的调节作用。

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Br J Pharmacol. 1981 Dec;74(4):757P-988P.

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Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone.神经甾体：少突胶质细胞线粒体将胆固醇转化为孕烯醇酮。

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Detection in bovine adrenal cortex of a lipoidal substance that yields pregnenolone upon treatment with alkali.在牛肾上腺皮质中检测到一种脂质物质，该物质经碱处理后可产生孕烯醇酮。

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