• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Unreliability of tritiated cholesterol: studies with [1,2-3H]-cholesterol and [24,25-3H]cholesterol in humans.氚标记胆固醇的不可靠性：[1,2-³H] -胆固醇和[24,25-³H] -胆固醇在人体中的研究
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2255-9. doi: 10.1073/pnas.77.4.2255.
2
Loss of tritium from coprostanone derived from [1,2(n)-3H]cholesterol or [7(n)-3H]cholesterol.源自[1,2(n)-3H]胆固醇或[7(n)-3H]胆固醇的粪甾烷酮中氚的损失。
J Lipid Res. 1980 May;21(4):480-4.
3
Mechanism of secretion of biliary lipids. I. Role of bile canalicular and microsomal membranes in the synthesis and transport of biliary lecithin and cholesterol.胆汁脂质分泌机制。I.胆小管和微粒体膜在胆汁卵磷脂和胆固醇合成及转运中的作用。
J Clin Invest. 1975 Jan;55(1):105-14. doi: 10.1172/JCI107900.
4
Metabolism of high density lipoproteins reconstituted with [3H]cholesteryl ester and [14C]cholesterol in the rat, with special reference to the ovary.用[3H]胆固醇酯和[14C]胆固醇重构的大鼠高密度脂蛋白的代谢，特别涉及卵巢。
Endocrinology. 1985 Aug;117(2):502-10. doi: 10.1210/endo-117-2-502.
5
An acetylation method for the quantification of membrane lipids, including phospholipids, polyphosphoinositides and cholesterol.一种用于定量分析膜脂（包括磷脂、多磷酸肌醇和胆固醇）的乙酰化方法。
Biochem J. 1991 Mar 1;274 ( Pt 2)(Pt 2):375-9. doi: 10.1042/bj2740375.
6
[Biosynthesis of the labelled rifamycin B in the presence of different 14C- and 3H-precursors].[在不同的¹⁴C和³H前体存在下标记利福霉素B的生物合成]
Antibiotiki. 1978 Jan;23(1):31-4.
7
Mechanism of formation of the A/B cis ring junction of ecdysteroids in Polypodium vulgare.普通水龙骨中蜕皮甾体A/B顺式环连接的形成机制。
Biochem J. 1980 Sep 15;190(3):537-44. doi: 10.1042/bj1900537.
8
Estimation of glucose turnover and recycling in rabbits using various [3H, 14C]glucose labels.使用各种[3H, 14C]葡萄糖标记物估算兔体内葡萄糖的周转和再循环
Am J Physiol. 1976 Apr;230(4):1159-62. doi: 10.1152/ajplegacy.1976.230.4.1159.
9
Elimination of C-6-hydrogen during the formation of ecdysteroids from cholesterol in Locusta migratoria ovaries.在飞蝗卵巢中从胆固醇形成蜕皮甾体过程中C-6-氢的消除。
Steroids. 1989 Mar-May;53(3-5):477-85. doi: 10.1016/0039-128x(89)90026-3.
10
Effect of dietary vegetable (water convolvulus) on cholesterol metabolism in rats.膳食蔬菜（空心菜）对大鼠胆固醇代谢的影响。
J Nutr. 1984 Mar;114(3):503-10. doi: 10.1093/jn/114.3.503.

引用本文的文献

1
Microscale preparation of natural and labeled oxysterols.天然及标记氧甾醇的微量制备。
Lipids. 1996 May;31(5):529-34. doi: 10.1007/BF02522647.
2
In vivo influx of free and esterified plasma cholesterol into human aortic tissue without atherosclerotic lesions.在无动脉粥样硬化病变的人体主动脉组织中，游离及酯化血浆胆固醇的体内流入情况。
J Clin Invest. 1984 Nov;74(5):1871-81. doi: 10.1172/JCI111606.
3
Heterogeneity of cholesterol homeostasis in man. Response to changes in dietary fat quality and cholesterol quantity.人类胆固醇稳态的异质性。对膳食脂肪质量和胆固醇量变化的反应。
J Clin Invest. 1987 Jun;79(6):1729-39. doi: 10.1172/JCI113013.

本文引用的文献

1
ISOTOPE EFFECTS IN GAS-LIQUID CHROMATOGRAPHY OF STEROIDS.类固醇气液色谱中的同位素效应
J Lipid Res. 1965 Jan;6:7-9.
2
CLINICAL VALUE OF THE CORTISOL SECRETION RATE.皮质醇分泌率的临床价值
J Clin Pathol. 1965 Jan;18(1):82-7. doi: 10.1136/jcp.18.1.82.
3
Turnover of plasma cholesterol in man.人体血浆胆固醇的周转率。
J Clin Invest. 1968 Feb;47(2):231-41. doi: 10.1172/JCI105719.
4
1,2-3-H cholesterol as a tracer in studies of human cholesterol metabolism.1,2-3-H胆固醇作为人体胆固醇代谢研究中的示踪剂。
J Lipid Res. 1967 Jul;8(4):406-8.
5
Effect of tritium labeling of cortisol on its physical-chemical properties and on its metabolism in man.氢化可的松的氚标记对其理化性质及人体代谢的影响。
J Clin Endocrinol Metab. 1966 Feb;26(2):133-42. doi: 10.1210/jcem-26-2-133.
6
Improved separation of sterols by reversed-phase thin-layer chromatography.通过反相薄层色谱法改进甾醇的分离
J Lipid Res. 1969 Mar;10(2):240-3.
7
Measurements of cholesterol turnover, synthesis, and absorption in man, carried out by isotope kinetic and sterol balance methods.采用同位素动力学和甾醇平衡方法对人体胆固醇周转、合成及吸收进行的测量。
J Lipid Res. 1969 Jan;10(1):91-107.
8
Synthesis of 3 -hydroxy- 5 -steroids by sodium borohydride reduction of dienol trimethylsilyl ether derivatives of 3-oxo- 4 -steroids.通过硼氢化钠还原3-氧代-4-甾体的二烯醇三甲基硅醚衍生物合成3-羟基-5-甾体。
Steroids. 1971 Oct;18(4):381-8. doi: 10.1016/0039-128x(71)90052-3.
9
An evaluation of four methods for measuring cholesterol absorption by the intestine in man.人体肠道胆固醇吸收的四种测量方法评估。
J Lipid Res. 1971 Mar;12(2):221-32.
10
A simple and precise assay of the enzymatic conversion of cholesterol into pregnenolone.一种简单而精确的胆固醇向孕烯醇酮酶促转化测定法。
Biochemistry. 1974 Jan 29;13(3):603-9. doi: 10.1021/bi00700a031.

氚标记胆固醇的不可靠性：[1,2-³H] -胆固醇和[24,25-³H] -胆固醇在人体中的研究

Unreliability of tritiated cholesterol: studies with [1,2-3H]-cholesterol and [24,25-3H]cholesterol in humans.

作者信息

Davidson N O, Ahrens E H, Bradlow H L, McNamara D J, Parker T S, Samuel P

出版信息

Proc Natl Acad Sci U S A. 1980 Apr;77(4):2255-9. doi: 10.1073/pnas.77.4.2255.

DOI:10.1073/pnas.77.4.2255
PMID:6929548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC348692/
Abstract

Over the past 18 months different lots of [1,2-3H]cholesterol and [24,25-3H]cholesterol were found to be radiochemically acceptable by conventional chemical and other in vitro tests, yet, when co-administered with [4-14C]cholesterol to human subjects, an abrupt fall in the 3H/14C specific activity ratio in plasma cholesterol was discovered in every case. We have concluded that all batches of [3H]cholesterol should be regarded as radiochemically unreliable unless they are shown to behave identically in all respects to [4-14C]cholesterol in an appropriate in vivo assay system.

摘要

在过去18个月里，通过常规化学和其他体外试验发现，不同批次的[1,2 - 3H]胆固醇和[24,25 - 3H]胆固醇在放射化学方面是可接受的。然而，当与[4 - 14C]胆固醇共同给予人体受试者时，在每种情况下都发现血浆胆固醇中3H/14C比活度比值突然下降。我们得出结论，所有批次的[3H]胆固醇都应被视为放射化学不可靠，除非它们在适当的体内测定系统中在所有方面都表现得与[4 - 14C]胆固醇相同。