维生素C在DNA合成抑制试验和姐妹染色单体交换试验中呈阳性。
Vitamin C is positive in the DNA synthesis inhibition and sister-chromatid exchange tests.
作者信息
Galloway S M, Painter R B
出版信息
Mutat Res. 1979 May;60(3):321-7. doi: 10.1016/0027-5107(79)90022-8.
Ascorbate caused a dose-dependent increase in sister-chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells and in human lymphocytes. Moreover, in the DNA synthesis inhibition test with HeLa cells, ascorbate gave results typical of DNA-damaging chemicals. Catalase reduced SCE induction by ascorbate, prevented its cytotoxicity in CHO cells, and prevented its effect on HeLa DNA synthesis. Ascorbate reduced induction of SCE in CHO cells by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) by direct inactivation of MNNG.
抗坏血酸盐可使中国仓鼠卵巢（CHO）细胞和人淋巴细胞中的姐妹染色单体交换（SCE）呈剂量依赖性增加。此外，在对HeLa细胞进行的DNA合成抑制试验中，抗坏血酸盐给出了典型的DNA损伤化学物质的结果。过氧化氢酶可降低抗坏血酸盐诱导的SCE，防止其对CHO细胞产生细胞毒性，并防止其对HeLa细胞DNA合成的影响。抗坏血酸盐通过直接使N-甲基-N'-硝基-N-亚硝基胍（MNNG）失活，降低了MNNG对CHO细胞SCE的诱导作用。
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