Thomson V E, Evans H J
Mutat Res. 1979 May;67(1):47-53. doi: 10.1016/0165-1218(79)90098-3.
The effect of a 1-h exposure to aflatoxin B1 (AFB1) in inducing sister-chromatid exchange in Chinese hamster ovary (CHO) cells and human lymphocytes in the presence or absence of mixed function oxidase ("S9 mix") was compared. CHO cells were also exposed to a graded series of doses of N-methyl-N-nitrosourea, a powerful inducer of SCE whose action was independent of the presence or absence of S9 mix. CHO and human cells showed a close correlation in response to SCE induction by AFB1 and in both cell systems the additon of mixed function oxidases in the S9 mix resulted in a marked enhancement of action of AFB1.
比较了在存在或不存在混合功能氧化酶（“S9混合液”）的情况下，黄曲霉毒素B1（AFB1）1小时暴露对中国仓鼠卵巢（CHO）细胞和人淋巴细胞中姐妹染色单体交换的诱导作用。CHO细胞还暴露于一系列梯度剂量的N-甲基-N-亚硝基脲中，N-甲基-N-亚硝基脲是一种强大的SCE诱导剂，其作用与S9混合液的存在与否无关。CHO细胞和人细胞对AFB1诱导SCE的反应密切相关，并且在这两种细胞系统中，S9混合液中混合功能氧化酶的添加导致AFB1的作用显著增强。
