实验大鼠（褐家鼠）中甲基乙二醛脱氢酶的生化遗传学
Biochemical genetics of methylglyoxal dehydrogenases in the laboratory rat (Rattus norvegicus).
作者信息
Bender K, Seibert R T, Wienker T F, Kren V, Pravenec M, Bissbort S
机构信息
Institut für Humangenetik und Anthropologie, Universität Freiburg, Germany.
出版信息
Biochem Genet. 1994 Jun;32(5-6):147-54. doi: 10.1007/BF00554618.
A genetic locus controlling the electrophoretic mobility of a methylglyoxal dehydrogenase (EC 1.2.1.23) in the rat is described. The locus, designated Mgd1, is expressed in liver and kidney. Inbred rat strains have fixed either allele Mgd1a or allele Mgd1b. Codominant expression is observed in heterozygotes, providing evidence for a tetrameric enzyme structure. Backcross progenies showed the expected 1:1 segregation ratio, and there is evidence that Mgd1 is linked to Pep3 and Fh1 on chromosome 13. There is also evidence for two additional methylglyoxal dehydrogenases: Mgd2, present in liver and kidney, and Mgd3, present only in heart.
描述了一个控制大鼠甲基乙二醛脱氢酶（EC 1.2.1.23）电泳迁移率的基因座。该基因座命名为Mgd1，在肝脏和肾脏中表达。近交系大鼠品系固定了等位基因Mgd1a或等位基因Mgd1b。在杂合子中观察到共显性表达，为四聚体酶结构提供了证据。回交后代显示出预期的1:1分离比，并且有证据表明Mgd1与13号染色体上的Pep3和Fh1连锁。还有证据表明存在另外两种甲基乙二醛脱氢酶：Mgd2，存在于肝脏和肾脏中；Mgd3，仅存在于心脏中。
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