Goldberg R N, Cabal L A, Sinatra F R, Plajstek C E, Hodgman J E
Pediatrics. 1979 Sep;64(3):336-41.
Twelve infants with severe perinatal asphyxia were found to have elevated blood ammonia levels (302 to 960 microgram/100 ml). In the seven survivors, hyperammonemia was associated with CNS irritability, hyperthermia, hypertension, and wide neonatal heart rate oscillations. Follow-up examinations revealed severe neurologic dysfunction in five of seven infants. CNS depression, hyperthermia, hypertension, and a nonreactive, fixed heart rate characterized the infants that died. These findings suggest a clinical entity secondary to perinatal asphyxia whose signs and symptoms may be related to hyperammonemia.
12名患有严重围产期窒息的婴儿被发现血氨水平升高（302至960微克/100毫升）。在7名幸存者中，高氨血症与中枢神经系统易激惹、体温过高、高血压及新生儿心率大幅波动有关。随访检查显示，7名婴儿中有5名存在严重神经功能障碍。死亡婴儿的特征为中枢神经系统抑制、体温过高、高血压及心率无反应、固定不变。这些发现提示存在一种围产期窒息继发的临床病症，其体征和症状可能与高氨血症有关。
