多发性硬化症中的脑脊液蛋白质
Cerebrospinal fluid proteins in multiple sclerosis.
作者信息
Lamoureux G, Jolicoeur R, Giard N, St-Hilaire M, Duplantis F
出版信息
Neurology. 1975 Jun;25(6):537-46. doi: 10.1212/wnl.25.6.537.
Various CSF proteins were studied in 255 definite multiple sclerosis patients at various disease stages and compared with corresponding values obtained from 174 controls. The CSF changes in acute multiple sclerosis patients included a significant increase of total proteins and of gamma globulin, IgG, IgA, IgM, alpha-2 ceruloplasmin, 7S-gamma-1, and cytotoxic index for nerve cells in tissue culture, and significant decreases of pre-albumin, alpha-1, and alpha-2 and of the beta/gamma globulin ratio. The CSF levels of IgG, IgA, and IgM remained significantly higher in steroid-treated multiple sclerosis patients than in controls, but the levels often were significantly reduced while patients were on treatment or in remission. During remission or treatment with ACTH and/or steroids, the alpha-2 ceruloplasmin, 7S-gamma-1, and cytotoxic index were significantly reduced and the pre-albumin, alpha-1, and alpha-2 globulin classes and the beta/gamma ratio showed a tendency to return to normal.
对255例处于不同疾病阶段的明确多发性硬化症患者的各种脑脊液蛋白进行了研究，并与174例对照者的相应数值进行了比较。急性多发性硬化症患者的脑脊液变化包括总蛋白、γ球蛋白、IgG、IgA、IgM、α-2铜蓝蛋白、7S-γ-1以及组织培养中神经细胞的细胞毒性指数显著增加，前白蛋白、α-1和α-2以及β/γ球蛋白比值显著降低。接受类固醇治疗的多发性硬化症患者脑脊液中IgG、IgA和IgM水平仍显著高于对照组，但在患者接受治疗或缓解期间，这些水平通常会显著降低。在缓解期或接受促肾上腺皮质激素和/或类固醇治疗期间，α-2铜蓝蛋白、7S-γ-1和细胞毒性指数显著降低，前白蛋白、α-1和α-2球蛋白类别以及β/γ比值有恢复正常的趋势。
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