Hybelová M, Svatonová J, Sobek O, Adam P, Dolezil D, Adam D
Laboratory of Reference for CSF and Neuroimmunology, Department of Clinical Biochemistry, Homolka Hospital, Prague, Czech Republic.
Folia Microbiol (Praha). 2009;54(2):173-6. doi: 10.1007/s12223-009-0027-4. Epub 2009 May 6.
The levels of prealbumin (PAB, transthyretin) were determined and evaluated in the cerebrospinal fluid (CSF) and serum in various subgroups of the multiple sclerosis (MS) patients. In severely disabled patients, serum PAB was elevated more frequently. CSF and serum PAB concentrations were higher in treated than in nontreated patients; the values above the upper reference limits were also more frequently found in treated patients. PAB index showed a tendency to decrease during the course of the disease. The routine determination of PAB in CSF and serum is, therefore, recommended to be recognized in MS patients as a substantial clinical value and, thus, be comprised, including also immunoglobulins and other parameters, into the spectrum of characteristics in Protein Panel.
在多发性硬化症（MS）患者的各个亚组中，测定并评估了脑脊液（CSF）和血清中前白蛋白（PAB，转甲状腺素蛋白）的水平。在重度残疾患者中，血清PAB升高更为常见。治疗患者的脑脊液和血清PAB浓度高于未治疗患者；治疗患者中也更频繁地发现高于参考上限的值。PAB指数在疾病过程中呈下降趋势。因此，建议对脑脊液和血清中的PAB进行常规测定，以便在MS患者中被视为具有重要临床价值，从而与免疫球蛋白和其他参数一起纳入蛋白质组特征谱中。
