支原体病毒MVL51的细胞内复制

Intracellular replication of mycoplasmavirus MVL51.

作者信息

Liss A, Maniloff J

出版信息

J Virol. 1974 Apr;13(4):769-74. doi: 10.1128/JVI.13.4.769-774.1974.

DOI:10.1128/JVI.13.4.769-774.1974

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC355374/

Abstract

The intracellular replication of MVL51, a group L1 mycoplasmavirus, was investigated. The single-stranded parental DNA was found to enter the cell and become converted to double-stranded DNA. This replicated to yield additional double-stranded DNA molecules. The parental viral DNA was found to leave the replication complex and become associated with large molecular weight DNA not involved with viral replication. Progeny viral DNA formed from the double-stranded DNA and an intracellular accumulation of virus chromosome size DNA was observed. The interpretation of this data and a suggested model for the viral replication are discussed and compared to viral DNA replication models for other single-stranded DNA viruses.

摘要

对L1组支原体病毒MVL51的细胞内复制进行了研究。发现单链亲代DNA进入细胞并转化为双链DNA。该双链DNA进行复制以产生更多双链DNA分子。发现亲代病毒DNA离开复制复合体并与不参与病毒复制的大分子DNA结合。观察到由双链DNA形成的子代病毒DNA以及病毒染色体大小DNA的细胞内积累。讨论了这些数据的解释以及病毒复制的建议模型，并与其他单链DNA病毒的病毒DNA复制模型进行了比较。

相似文献

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Intracellular replication of mycoplasmavirus MVL51.支原体病毒MVL51的细胞内复制

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