葡萄糖和氯化钾对渗透感受器减慢胃排空的作用。
Actions of glucose and potassium chloride on osmoreceptors slowing gastric emptying.
作者信息
Barker G R, Cochrane G M, Corbett G A, Hunt J N, Roberts S K
出版信息
J Physiol. 1974 Feb;237(1):183-6. doi: 10.1113/jphysiol.1974.sp010476.
Abstract
- Five subjects were given 373 test meals of 750 ml. water containing a range of concentrations of glucose or potassium chloride.2. The greater the concentration of solute in the meals, the greater was the volume of the test meal recovered from the stomach after a fixed time.3. When the concentrations of the solutes were expressed as m-osmole/l. corrected by osmotic coefficients based on vapour pressures at 37 degrees C, glucose and potassium chloride were indistinguishable in slowing gastric emptying.4. These results are consistent with the regulation of gastric emptying by a duodenal receptor responding to osmotic pressure.5. Potassium chloride was more nauseating than glucose on an osmolar basis.
摘要
给5名受试者提供了373份750毫升的测试餐，餐中含有一系列浓度的葡萄糖或氯化钾。
餐中溶质浓度越高，在固定时间后从胃中回收的测试餐体积就越大。
当溶质浓度以37摄氏度时基于蒸气压的渗透系数校正后的毫渗透压摩尔/升表示时，葡萄糖和氯化钾在减缓胃排空方面没有区别。
这些结果与十二指肠受体对渗透压作出反应来调节胃排空的观点一致。
以渗透压为基础，氯化钾比葡萄糖更易引起恶心。
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