测试餐中，单糖和双糖对胃排空的延缓作用。

The slowing of gastric emptying by monosaccharides and disaccharides in test meals.

作者信息

Elias E, Gibson G J, Greenwood L F, Hunt J N, Tripp J H

出版信息

J Physiol. 1968 Feb;194(2):317-26. doi: 10.1113/jphysiol.1968.sp008410.

DOI:10.1113/jphysiol.1968.sp008410

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1365795/

Abstract

Test meals containing various concentrations of glucose, maltose, sucrose, fructose, lactose, galactose and mixtures of these solutes were given to six healthy subjects. All meals contained 40 mM sodium citrate.2. The slowing of gastric emptying produced by the disaccharides in test meals was generally consistent with the stimulation of duodenal osmoreceptors occuring after the hydrolysis of the disaccharides.3. Glucose was slightly more effective, per osmole, in slowing gastric emptying than was galactose.4. By comparison with glucose or galactose, fructose was much less effective in slowing gastric emptying. In three subjects out of six there was a threshold for its effect.5. The results may be indicative of the relative activities of disaccharidases in the brush border of the small intestine. They are consistent with there being an osmoreceptor deep to these enzymes which slows gastric emptying.

摘要

给6名健康受试者提供含有不同浓度葡萄糖、麦芽糖、蔗糖、果糖、乳糖、半乳糖以及这些溶质混合物的试验餐。所有餐食均含有40 mM柠檬酸钠。
试验餐中双糖导致的胃排空减慢通常与双糖水解后发生的十二指肠渗透压感受器刺激相一致。
每摩尔葡萄糖在减慢胃排空方面比半乳糖略有效。
与葡萄糖或半乳糖相比，果糖在减慢胃排空方面效果要差得多。6名受试者中有3名存在其作用阈值。
这些结果可能表明小肠刷状缘中双糖酶的相对活性。它们与这些酶下方存在一个减慢胃排空的渗透压感受器相一致。