Woelk H
Arzneimittelforschung. 1982;32(3):207-10.
Investigations on the incorporation of intraventricularly injected 32P in neuronal and glial phosphatidylinositol, phosphatidylserine, phosphatidylcholine, phosphatidylethanolamine and ethanolamine plasmalogen at intervals ranging from 5 to 60 min showed different incorporation rates of the radioactive precursor into neuronal and glial phosphatides. The incorporation rate of 32P into the different glycerophosphatides was faster in neurons as compared to the gliocyte compartment. Phosphatidylinositol showed the fastest and ethanolamine plasmalogen the slowest incorporation of 32P in both neurons and gliocytes. Centrophenoxine (meclofenoxate, Helfergin) increased the incorporation of 32P into phosphatidylserine and ethanolamine plasmalogen of both glial and neuronal cell bodies whereas the incorporation of the radioactive precursor into phosphatidylcholine was slightly inhibited. The incorporation rate into phosphatidylinositol and phosphatidylethanolamine was not influenced by centrophenoxine. The data obtained in the present work suggest that centrophenoxine may stimulate excitatory neurons and may be involved in the process of synaptic transmission and axonal conduction.
对脑室内注射的32P在神经元和胶质细胞的磷脂酰肌醇、磷脂酰丝氨酸、磷脂酰胆碱、磷脂酰乙醇胺和乙醇胺缩醛磷脂中的掺入情况进行的研究，时间间隔为5至60分钟，结果显示放射性前体在神经元和胶质细胞磷脂中的掺入率不同。与胶质细胞区室相比，32P在神经元中掺入不同甘油磷脂的速率更快。在神经元和胶质细胞中，磷脂酰肌醇显示出32P的掺入最快，而乙醇胺缩醛磷脂的掺入最慢。氯酯醒（甲氯芬酯，海弗林）增加了32P掺入胶质细胞和神经元细胞体的磷脂酰丝氨酸和乙醇胺缩醛磷脂中，而放射性前体掺入磷脂酰胆碱的过程则受到轻微抑制。氯酯醒对磷脂酰肌醇和磷脂酰乙醇胺的掺入率没有影响。本研究获得的数据表明，氯酯醒可能刺激兴奋性神经元，并可能参与突触传递和轴突传导过程。
