天然存在的小鼠抗脑自身抗体检测到的种间脑抗原。
Interspecies brain antigen detected by naturally occurring mouse anti-brain autoantibody.
作者信息
Martin S E, Martin W J
出版信息
Proc Natl Acad Sci U S A. 1975 Mar;72(3):1036-40. doi: 10.1073/pnas.72.3.1036.
Abstract
Normal mouse sera contain naturally occurring antibodies that are cytotoxic in the presence of rabbit complement for NB1, a cell line derived from a neuroblastoma adrenal metastasis of a spontaneous ovarian teratoma. The anti-NB1 antibodies can be specifically removed from normal mouse sera by absorption of the sera with homogenized brain tissue of mouse, rat, guinea pig, chicken, and man and by homogenized kidney tissue of mouse and man. The antigen recognized by anti-NB1 naturally occurring autoantibodies, designated mouse brain antigen-2 (MBA-2), is not present on other normal tissues or tumor cell lines tested. MBA-2 is distinct from previously described mouse brain antigens.
摘要
正常小鼠血清中含有天然存在的抗体，在兔补体存在的情况下，这些抗体对NB1具有细胞毒性，NB1是一种源自自发性卵巢畸胎瘤肾上腺转移神经母细胞瘤的细胞系。通过用小鼠、大鼠、豚鼠、鸡和人的脑组织匀浆以及小鼠和人的肾组织匀浆吸收血清，可以从正常小鼠血清中特异性去除抗NB1抗体。抗NB1天然自身抗体识别的抗原，称为小鼠脑抗原-2（MBA-2），在其他测试的正常组织或肿瘤细胞系中不存在。MBA-2与先前描述的小鼠脑抗原不同。
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