血管加压素对左心房扩张所致利尿反应的影响。

The effects of vasopressin on the diuretic response to left atrial distension.

Ledsome J R, Mason J M

J Physiol. 1972 Mar;221(2):427-40. doi: 10.1113/jphysiol.1972.sp009759.

Abstract

The diuretic response to left atrial distension was studied during infusion of saline or during infusion of vasopressin at four different dose rates.2. During infusion of saline left atrial distension caused an increase in free water clearance and an increase in osmolal clearance.3. During infusion of vasopressin at a rate of 0.025 m-u./kg.min and 0.1 m-u./kg.min there was no statistically significant increase in free water clearance during left atrial distension but there were variations in free water clearance in individual experiments.4. During infusion of vasopressin in doses of 0.4 m-u./kg.min and 1.0 m-u./kg.min changes in free water clearance were dependent upon changes in osmolal clearance indicating that these doses of vasopressin provided a maximum antidiuretic effect.5. Infusion of vasopressin had no effect on the increase in osmolal clearance which occurred in response to left atrial distension.6. The results allow the view that a part of the diuretic response to left atrial distension could depend upon a decrease in the concentration of antidiuretic hormone in the circulating blood.

摘要

在输注生理盐水或四种不同剂量率的血管加压素期间，研究了左心房扩张的利尿反应。
在输注生理盐水期间，左心房扩张导致自由水清除率增加和渗透清除率增加。
在以0.025 m - u./kg.min和0.1 m - u./kg.min的速率输注血管加压素期间，左心房扩张时自由水清除率无统计学显著增加，但个别实验中自由水清除率存在变化。
在以0.4 m - u./kg.min和1.0 m - u./kg.min的剂量输注血管加压素期间，自由水清除率的变化取决于渗透清除率的变化，表明这些剂量的血管加压素产生了最大抗利尿作用。
血管加压素输注对因左心房扩张而发生的渗透清除率增加无影响。
这些结果支持这样一种观点，即对左心房扩张的部分利尿反应可能取决于循环血液中抗利尿激素浓度的降低。