Preston F E, Malia R G, Sworn M J, Timperley W R, Blackburn E K
J Neurol Neurosurg Psychiatry. 1974 Mar;37(3):241-8. doi: 10.1136/jnnp.37.3.241.
Three cases with intracranial lesions developed evidence of disseminated intravascular coagulation which was confirmed at necropsy. The factors engendering this state, including release of potent thromboplastin from neural tissue are discussed and the danger of this intermediary mechanism of disease increasing the mortality of intracranial disease is demonstrated. Careful haematological investigation of all patients with intracranial disease is therefore advised, especially if they manifest evidence of a bleeding tendency.
3例颅内病变患者出现弥散性血管内凝血的证据，尸检得以证实。文中讨论了引发这种状态的因素，包括神经组织释放强效凝血活酶，并证明了这种疾病的中间机制会增加颅内疾病死亡率的危险性。因此，建议对所有颅内疾病患者进行仔细的血液学检查，尤其是那些有出血倾向证据的患者。
