Auer L
Acta Neurochir (Wien). 1978;43(1-2):51-9. doi: 10.1007/BF01809225.
This is an investigation into thromboplastin time, partial thromboplastin time, plasma thrombin time, fibrinogen, and platelets in 30 patients with severe brain injury over 7--14 days. Platelets showed a very marked initial decrease and a slow return to normal around the seventh day. Fibrinogen was initially lowered in most of the cases, and raised from the second day onward. Changes in the other laboratory values were less definite. Latent signs of consumption coagulopathy were not accompanied by bleeding disorders, or by disseminated intravascular coagulation at autopsy. The severity of laboratory value changes clearly correlated with the extent of brain damage, and was significantly higher when the patient did not survive the first week after injury.
这是一项对30例重度脑损伤患者在7至14天内的凝血活酶时间、部分凝血活酶时间、血浆凝血酶时间、纤维蛋白原和血小板进行的调查。血小板最初显著减少，并在第七天左右缓慢恢复正常。大多数病例中纤维蛋白原最初降低，从第二天起升高。其他实验室值的变化不太明确。消耗性凝血病的潜在迹象在尸检时未伴有出血性疾病或弥散性血管内凝血。实验室值变化的严重程度与脑损伤程度明显相关，且在患者伤后第一周内未存活时显著更高。
