Higenbottam T, Crome P, Parkinson C, Nunn J
Thorax. 1979 Apr;34(2):161-5. doi: 10.1136/thx.34.2.161.
Five patients are reported who developed evidence of acute lung damage after proved ingestion of paraquat. In two the lung changes resolved; in one an aspiration pneumonia occurred, which was successfully treated, while two developed fatal pulmonary oedema. These pulmonary complications after paraquat intoxication appear more common than the progressive pulmonary fibrosis previously described. It is suggested that acute pulmonary oedema is a response to large doses, usually of Gramoxone, that subclinical lung changes result from small doses, usually of Weedol, and that pulmonary fibrosis occurs after intermediate doses. Preliminary data on plasma paraquat concentrations suggest that these are of value in prognosis.
报告了5例患者，在证实摄入百草枯后出现急性肺损伤的证据。其中2例肺部病变消退；1例发生吸入性肺炎，经成功治疗，而2例发生致命性肺水肿。百草枯中毒后的这些肺部并发症似乎比先前描述的进行性肺纤维化更常见。有人认为，急性肺水肿是对大剂量（通常是克无踪）的反应，亚临床肺部变化是由小剂量（通常是威多灵）引起的，而肺纤维化发生在中等剂量之后。血浆百草枯浓度的初步数据表明，这些数据对预后有价值。
