Lewis M L
J Clin Pathol. 1974 Mar;27(3):242-6. doi: 10.1136/jcp.27.3.242.
Severe cyclic thrombocytopenia is reported in a young woman. This rare phenomenon is of considerable theoretical interest in relation to platelet kinetics. In this patient platelet and fibrinogen survival times exclude the possibility of excessive peripheral platelet destruction. Serial plasma thrombopoietin levels suggest that a deficiency of this protein may be the underlying factor. As a result platelet production may fall to a very low level. The megakaryocyte, however, remains responsive and the hypothesis advanced is that under these circumstances the intermenstrual platelet increase, normally caused by the interplay of the sex hormones, becomes grossly exaggerated.
据报道，一名年轻女性患有严重的周期性血小板减少症。这种罕见现象在血小板动力学方面具有相当大的理论研究价值。在该患者中，血小板和纤维蛋白原的存活时间排除了外周血小板过度破坏的可能性。连续的血浆血小板生成素水平表明，这种蛋白质的缺乏可能是潜在因素。因此，血小板生成可能降至极低水平。然而，巨核细胞仍然有反应，提出的假说是，在这种情况下，通常由性激素相互作用引起的月经间期血小板增加会变得极度夸张。
