Penington D G
Br Med J. 1970 Mar 7;1(5696):606-8. doi: 10.1136/bmj.1.5696.606.
An assay system has been developed in mice for the humoral agent "thrombopoietin." This is based on utilization in newly-formed platelets of the radio-amino-acid (75)Se selenomethionine 24 hours after intravenous injection. The possibility that the results could be due to the effects of species antibody, to foreign protein, or to an effect primarily on selenomethionine metabolism, has been explored, but the findings are consistent with the presence of a physiological humoral factor. Thrombopoietin has been shown to be present in the plasma of patients suffering from severe thrombocytopenia of varied aetiology.
已经在小鼠中开发出一种用于检测体液因子“血小板生成素”的测定系统。这是基于静脉注射24小时后，新生血小板对放射性氨基酸（75）Se硒代蛋氨酸的利用情况。已经探讨了结果可能是由于种属抗体、外来蛋白质的影响，或者主要是对硒代蛋氨酸代谢的影响，但研究结果与存在一种生理性体液因子相符。血小板生成素已被证明存在于患有各种病因的严重血小板减少症患者的血浆中。
