Belokhvostov A S, Grikurova N K
Vopr Onkol. 1981;27(12):56-9.
The effect of nucleic acids isolated from ascitic fluid of Ehrlich tumor and Zaidela's hepatoma on the survival rate of C3Ha mice inoculated with Ehrlich tumor cells was studied. While nucleic acid preparations suppressed the cytotoxicity of immune lymphocytes in vitro, they failed to increase frequency of tumor inoculation in vivo. The addition of nucleic acid preparation to tumor cells mixed with syngeneic lymphocytes did not block immune defense against tumor growth either. The differences in the effects of nucleic acid preparations in vivo and in vitro are discussed.
研究了从艾氏腹水瘤和齐德氏肝癌腹水中分离出的核酸对接种艾氏瘤细胞的C3Ha小鼠存活率的影响。虽然核酸制剂在体外抑制免疫淋巴细胞的细胞毒性，但它们未能提高体内肿瘤接种的频率。将核酸制剂添加到与同基因淋巴细胞混合的肿瘤细胞中，也不能阻断对肿瘤生长的免疫防御。文中讨论了核酸制剂在体内和体外作用的差异。
