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[保加利亚人民共和国大规模接种和复种疫苗后麻疹流行病学模式的动态变化]

[Dynamic changes in the epidemiological patterns of measles in the People's Republic of Bulgaria after mass vaccination and revaccination].

作者信息

Donchev D, Ranchov G, Gacheva N

出版信息

Vopr Virusol. 1979 Jul-Aug(4):417-22.

PMID:483777
Abstract

The main epidemiological regularities of measles before vaccination (1960--1968) and at the stage of mass vaccination (1969--1977) were studied. The average annual incidence of measles has been reduced from 423.97 to 279.72 per 100,000, mortality from 0.56 to 0.10 0/0000, and lethality from 0.13% to 0.04%. The dynamical changes of postvaccination immunity were uneven: in 1969 vaccinations covered 30.67%, in 1970 28.82%, in 1971 64.09%, in 1972 53.38%, in 1973 59.61%, in 1974 67.53%, and in 1975 69.04%. The level of herd immunity in those years was lower than the optimal (45.35%, 43.97%, 67.71%, 68.13%, 74.65%, 83.25%, and 84.63%, respectively). In the first part of 1976 a general immunoprophylactic campaign was carried out including vaccination of the unvaccinated children born in 1963--1975 and revaccination of all those vaccinated one year before the campaign. Primary vaccination increased the coverage by 11.25%, and revaccination increased the portion of seropositive subjects by 5.2%. As a result, a sufficiently high level of general herd immunity has been achieved (1976--96.02%, 1977--96.10%) and the incidence decreased accordingly (1976--192.69 0/0000, 1977--9.17 0/0000).

摘要

研究了疫苗接种前(1960 - 1968年)和大规模接种阶段(1969 - 1977年)麻疹的主要流行病学规律。麻疹的年平均发病率从每10万人423.97例降至279.72例,死亡率从0.56‰降至0.10‰,致死率从0.13%降至0.04%。接种后免疫力的动态变化不均衡:1969年接种覆盖率为30.67%,1970年为28.82%,1971年为64.09%,1972年为53.38%,1973年为59.61%,1974年为67.53%,1975年为69.04%。这些年群体免疫水平低于最佳水平(分别为45.35%、43.97%、67.71%、68.13%、74.65%、83.25%和84.63%)。1976年上半年开展了一次全面的免疫预防运动,包括对1963 - 1975年出生未接种的儿童进行接种以及对在运动前一年已接种的所有儿童进行复种。初次接种使覆盖率提高了11.25%,复种使血清阳性受试者比例提高了5.2%。结果,实现了足够高的总体群体免疫水平(1976年为96.02%,1977年为96.10%),发病率相应下降(1976年为192.69‰,1977年为9.17‰)。

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