Sejda J
Rev Infect Dis. 1983 May-Jun;5(3):564-7. doi: 10.1093/clinids/5.3.564.
Mass immunization against measles in the Czechoslovak Socialist Republic (CSSR) began in 1969 and utilized the Czechoslovak vaccine, which corresponds in its parameters to the further-attenuated measles vaccines. The immunization rate for relevant age groups of the population (i.e., children born in 1968-1980) is already 98%-99% in 1982. Measles morbidity decreased to less than 2% of the incidence before the introduction of immunization, and the mortality now is practically negligible. The decade 1972-1982 produced significant changes in epidemiologic characteristics of measles. Of importance is the gradual shift in the age distribution of affected children to older, nonimmunized age groups. Results of yearly immunologic surveys of a broad, randomly selected population sample have become the decisive criteria for evaluation of vaccine efficacy. The program of revaccination of all children was chosen as the optimal strategy for maintaining measles elimination. This program aims at ensuring a level of herd immunity in the whole population of greater than or equal to 95%.
捷克斯洛伐克社会主义共和国(捷克斯洛伐克)于1969年开始大规模麻疹免疫接种,使用的是捷克斯洛伐克疫苗,其参数与进一步减毒的麻疹疫苗相当。到1982年,相关年龄组人群(即1968 - 1980年出生的儿童)的免疫接种率已达98% - 99%。麻疹发病率降至免疫接种前发病率的2%以下,目前死亡率几乎可以忽略不计。1972 - 1982年这十年间,麻疹的流行病学特征发生了显著变化。重要的是,受影响儿童的年龄分布逐渐向年龄较大、未接种疫苗的年龄组转移。对广泛随机选取的人群样本进行的年度免疫调查结果已成为评估疫苗效力的决定性标准。为维持消除麻疹状态,选择对所有儿童进行复种的方案作为最佳策略。该方案旨在确保整个人群的群体免疫水平大于或等于95%。