[高纯度人绒毛膜促性腺激素对人淋巴细胞免疫能力及DNA修复系统的影响]
[The influence of highly purified hCG on the immunocompetence of human lymphocytes and DNA repair system].
作者信息
Mühlenstedt D, Kim M A
出版信息
Z Geburtshilfe Perinatol. 1979 Jun;183(3):189-94.
PHA-stimulation of human T-lymphocytes, a parameter of cellular immunocompetence, can be suppressed by highly purified human chorionic gonadotropin (hCG) in a dose-dependent manner. This was shown spectrophotometrically and by the mitosis index. Our results are in agreement with H3-thymidine incorporation studies. We further investigated the DNA repair system in UV-light- and hCG-explsed lymphocytes. It could be shown that DNA repair-replication is disturbed by hCG. Such repair disturbances may cause reduced H3-thymidine incorporation in PHA-stimulated and hCG-treated lymphocytes. It is probably on this molecular level that hCG influences the immunocompetence of human lymphocytes.
人绒毛膜促性腺激素（hCG）对人T淋巴细胞的PHA刺激（细胞免疫能力的一个参数）具有剂量依赖性抑制作用。这通过分光光度法和有丝分裂指数得以证明。我们的结果与³H-胸腺嘧啶核苷掺入研究一致。我们进一步研究了紫外线和hCG处理的淋巴细胞中的DNA修复系统。结果表明，hCG会干扰DNA修复复制。这种修复干扰可能导致³H-胸腺嘧啶核苷掺入PHA刺激和hCG处理的淋巴细胞减少。hCG可能正是在这个分子水平上影响人淋巴细胞的免疫能力。
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