Morse J H
Scand J Immunol. 1976;5(6-7):779-87. doi: 10.1111/j.1365-3083.1976.tb03027.x.
Crude preparations of human chorionic gonadotropin (hCG) inhibited phytohemagglutinin (PHA) and allogeneic cell (MLC) lymphocyte stimulation of human peripheral blood lymphocytes (PBL) in vitro as measured by [3H]thymidine incorporation, whereas purified hCG was not inhibitory except at very high concentrations. Sephadex G-100 chromatography of crude hCG showed that the inhibitory effect on PHA lymphocyte stimulation eluted in those fractions after hormonally active hCG. In addition, purified human placental lactogen (hPL) did not inhibit lymphocyte transformation except at very high concentrations. These data suggest that the immunosuppressive activities found in crude preparations are not due to the hormones but to contaminating material.
人绒毛膜促性腺激素（hCG）的粗制品在体外可抑制植物血凝素（PHA）和人外周血淋巴细胞（PBL）的同种异体细胞（混合淋巴细胞培养，MLC）淋巴细胞刺激，这通过[³H]胸腺嘧啶核苷掺入来测定，而纯化的hCG除了在非常高的浓度下没有抑制作用。粗制hCG的葡聚糖凝胶G - 100层析显示，对PHA淋巴细胞刺激的抑制作用在具有激素活性的hCG之后的那些组分中洗脱出来。此外，纯化的人胎盘催乳素（hPL）除了在非常高的浓度下不抑制淋巴细胞转化。这些数据表明，在粗制品中发现的免疫抑制活性不是由于激素，而是由于污染物质。
