Han T
Immunology. 1975 Sep;29(3):509-15.
An inhibitory effect of human chorionic gonadotropin (HCG) on delayed hypersensitivity skin test responses in guinea-pigs given 4000 i.u. of HCG intraperitoneally, 1--7 days prior to skin testing, is presented. The effect of HCG on skin test responses lasted for at least 3 weeks. Inhibition of lymphocyte response to PHA or PPD in the HCG-treated guinea-pigs was also observed. Guinea-pig peripheral blood lymphocyte response to mitogen or antigen is unequivocally inhibited by HCG in vitro. The effect of this hormone is not due to direct cytotoxicity, and its inhibitory effect seems to be dose related. These observations support the hypothesis that the HCG and possibly other placental hormones might play an important role in protecting the foetus against maternal rejection.
本文提出,在豚鼠皮肤试验前1至7天腹腔注射4000国际单位人绒毛膜促性腺激素(HCG),可抑制其迟发型超敏皮肤试验反应。HCG对皮肤试验反应的影响持续至少3周。还观察到,经HCG处理的豚鼠对PHA或PPD的淋巴细胞反应受到抑制。在体外,HCG可明确抑制豚鼠外周血淋巴细胞对有丝分裂原或抗原的反应。该激素的作用并非由于直接细胞毒性,其抑制作用似乎与剂量相关。这些观察结果支持以下假说:HCG以及可能的其他胎盘激素在保护胎儿免受母体排斥方面可能发挥重要作用。